Sudeshna Ghosh

About

I am interested in exploring the role of chaperones against aggregation of amyloid beta peptides using a combination of experimental and theoretical approach. Interaction of small heat shock protein with relevant Human-amyloid beta peptides using spectroscopy and microscopy will be of interest. Expression, isolation and purification of the small heat shock proteins will be carried out using high-pressure liquid chromatography. Apart from their interaction with amyloid beta peptides, purified chaperones will be immobilized to design heat-shock resistant surface for the prevention of Alzheimer's.

Employment

• Indian Institute of Technology Kanpur DST-Inspire Faculty
  2017 - 2023
• Technion Israel Institute of Technology Postdoctoral Researcher
  2014 - 2016

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (20)

• Aβ-oligomers: A potential therapeutic target for Alzheimer's disease
  Elsevier 2023
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• Carvedilol inhibits Aβ25-35 fibrillation by intervening the early stage helical intermediate formation: A biophysical investigation.
  International journal of biological macromolecules 2021 DOI: 10.1016/j.ijbiomac.2021.08.028
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• Biophysical and structural characterization of the small heat shock protein HspA from Thermosynechococcus vulcanus in 2 M urea
  Biochimica et Biophysica Acta - Proteins and Proteomics 2019 DOI: 10.1016/j.bbapap.2018.12.011
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• DNA melting properties of the dityrosine cross-linked dimer of Ribonuclease A
  Journal of Photochemistry and Photobiology B: Biology 2016 DOI: 10.1016/j.jphotobiol.2016.06.056
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• An insight into the ribonucleolytic and antiangiogenic activity of buffalo lactoferrin
  Journal of Biomolecular Structure and Dynamics 2015 DOI: 10.1080/07391102.2013.865564
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• Copper(II) directs formation of toxic amorphous aggregates resulting in inhibition of hen egg white lysozyme fibrillation under alkaline salt-mediated conditions
  Journal of Biomolecular Structure and Dynamics 2015 DOI: 10.1080/07391102.2014.921864
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• Effect of temperature and solvent on fibrillation of human serum albumin
  Protein and Peptide Letters 2015 DOI: 10.2174/0929866521666140320104409
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• Evidence of two oxidation states of copper during aggregation of hen egg white lysozyme (HEWL)
  International Journal of Biological Macromolecules 2015 DOI: 10.1016/j.ijbiomac.2015.02.014
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• Fibrillation of human serum albumin shows nonspecific coordination on stoichiometric increment of Copper(II)
  Journal of Biomolecular Structure and Dynamics 2014 DOI: 10.1080/07391102.2013.819300
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• Disruption of human serum albumin fibrils by a static electric field
  Journal of Physics D: Applied Physics 2014 DOI: 10.1088/0022-3727/47/30/305401
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