HOMEN PHUKAN

About

I am a Postdoctoral Researcher at the University of Gothenburg, Sweden, supported by the DDLS (SciLifeLab) program. I hold an MSc in Biotechnology and a PhD in Medical Microbiology from ICMR-Regional Medical Research centre, Sri Vijaya Puram, Port Blair and Pondicherry University, India, with a specialisation in microbial proteomics. My earlier research focused on the outer membrane proteins of Leptospira, establishing expertise in subcellular fractionation, proteome profiling, and biomarker discovery. My current work centers on the proteomics of Helicobacter pylori, class I carcinogen of gastric cancer, particularly the characterization of a newly discovered ecospecies associated with high gastric-cancer risk. I focus on mapping outer membrane protein (OMP) repertoires, virulence factors, and regulatory mechanisms that shape H. pylori pathogenicity.

Employment

• University of Gothenburg DDLS PostDoc (SciLifeLab)
  2024 - Present
• Regional Medical Research Centre ICMR- Senior Research Fellow
  2021 - 2024
• Advanced Level Institutional Biotech Hub, North Lakhimpur College DBT- Junior Research Fellow
  2017 - 2018

Education

• St.Anthony's College MSc
  2014 - 2016
• Gauhati University BSc
  2011 - 2014

Projects & Funding

Projects & funding information is unavailable.

Publications (11)

• Enriching Subcellular Proteins in Leptospira Using a Triton X-114-Based Fractionation Approach
  Journal of Visualized Experiments 2025 DOI: 10.3791/67298
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• Exoproteome Profiling Reveals Increased Secretion of Adhesins and Proteases by Leptospira interrogans to Facilitate Host Colonization and Immune Modulation
  ACS Omega 2025 DOI: 10.1021/acsomega.4c10983
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• One-step Extraction and Zymographic Analysis of Bacterial Gelatinases
  Journal of Visualized Experiments 2025 DOI: 10.3791/67291
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• Physiological Temperature and Osmotic Changes Drive Dynamic Proteome Alterations in the Leptospiral Outer Membrane and Enhance Protein Export Systems
  Journal of Proteome Research 2023 DOI: 10.1021/acs.jproteome.3c00295
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• Leptospiral cell wall hydrolase (LIC_10271) binding peptidoglycan, lipopolysaccharide, and laminin and the protein show LysM and M23 domains are co-existing in pathogenic species
  Research in Microbiology 2023 DOI: 10.1016/j.resmic.2023.104107
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• Leptospiral imelysin (LIC_10713) is secretory, immunogenic and binds to laminin, fibronectin, and collagen IV
  Applied Microbiology and Biotechnology 2023 DOI: 10.1007/s00253-023-12573-6
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• Unique Posttranslational Modification Sites of Acetylation, Citrullination, Glutarylation, and Phosphorylation Are Found to Be Specific to the Proteins Partitioned in the Triton X‑114 Fractions of Leptospira
  ACS Omega 2022 DOI: 10.1021/acsomega.2c01245
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• Leptospira and Leptospirosis: New Systems Science Insights on Proteome, Posttranslational Modifications, and Pathogen-Host Interaction
  OMICS: A Journal of Integrative Biology 2022 DOI: 10.1089/omi.2022.0007
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• Extracellular Proteome Analysis Shows the Abundance of Histidine Kinase Sensor Protein, DNA Helicase, Putative Lipoprotein Containing Peptidase M75 Domain and Peptidase C39 Domain Protein in Leptospira interrogans Grown in EMJH Medium
  Pathogens 2021 DOI: 10.3390/pathogens10070852
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• An in-silico approach to study the possible interactions of miRNA between human and SARS-CoV2
  Computational Biology and Chemistry 2020 DOI: 10.1016/j.compbiolchem.2020.107352
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