Kalyan Das

About

Field of research: Structural Biology, cryo-EM, structure-based drug design

Research interests: Research initiatives include investigating and targeting molecular machines and macromolecule assemblies using single-particle cryo-EM and X-ray crystallography techniques. Some of the key multidisciplinary and collaborative projects: (i) to understand mechanisms of viral and bacterial drug resistance, (ii) to elucidate molecular mechanisms such as – transcription initiation, elongation and regulation, mitochondrial DNA replication, DNA and RNA polymerization, RNA degradation, and ribosome – ER translocon complex, (iii) to study and target protein-protein and protein-nucleic acid interactions, (iv) use of fragment screening to generate hits and to identify new druggable sites, and (vii) hit-to-lead optimization.

Employment

• University of Alberta Professor and Canada Excellence Research Chair
  2024 - Present
• KU Leuven Research and Development Professor
  2017 - Present
• Rutgers University New Brunswick Research Professor
  2007 - 2017

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (171)

• Preferential remdesivir triphosphate incorporation by SARS-CoV-2 polymerase is altered to ATP by the S759A mutation
  Communications Biology 2026 DOI: 10.1038/s42003-026-09844-z
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• Protocol to investigate human mitochondrial transcription initiation by integrating biochemical and cryo-EM approaches
  STAR Protocols 2026 DOI: 10.1016/j.xpro.2025.104347
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• Structural basis for selective remdesivir incorporation by SARS-CoV-2 polymerase, and S759A resistance
  2025 DOI: 10.21203/rs.3.rs-7793649/v1
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• Structural basis for selective remdesivir incorporation by SARS-CoV-2 RNA polymerase, and S759A resistance
  2025 DOI: 10.1101/2025.09.04.674295
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• Human mitochondrial RNA polymerase structures reveal transcription start site and slippage mechanism
  Molecular Cell 2025 DOI: 10.1016/j.molcel.2025.07.002
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• Human mitochondrial RNA polymerase structures reveal transcription start-site and slippage mechanism
  2024 DOI: 10.1101/2024.12.02.626445
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• Structures illustrate step-by-step mitochondrial transcription initiation
  Nature 2023 DOI: 10.1038/s41586-023-06643-y
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• Yeast mtDNA transcription initiation in single nucleotide addition steps
  2022 DOI: 10.1101/2022.09.27.509796
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• Yeast mtDNA transcription initiation in single nucleotide addition steps
  2022 DOI: 10.21203/rs.3.rs-2082128/v1
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• Structural insights into TRAP association with ribosome-Sec61 complex, and translocon inhibition by a CADA derivative
  2022 DOI: 10.1101/2022.09.28.509949
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