Waseem Chauhan

About

I am a postdoctoral scholar at the Department of Physiology of University of Tennessee Health Science Center (UTHSC) in Memphis, Tennessee, where I also serve as Co-President of the UTHSC Postdoctoral Association. My research is dedicated to finding novel therapeutic strategies for sickle cell disease (SCD), focusing on the molecular mechanisms that drive SCD pathology with an emphasis on oxidative stress and the role of reactive oxygen species (ROS) in red blood cells, as well as their contribution to vaso-occlusive crises. I am deeply interested in non-coding RNAs, specifically small nucleolar RNAs (snoRNAs) from the Rpl13a locus, and have identified Rpl13a snoRNAs U34 and U35a as promising new therapeutic targets, demonstrating that targeting these snoRNAs with antisense oligonucleotides can reduce ROS generation, improve blood flow, and reduce mortality in preclinical models. Additionally, I have reviewed the potential of the Keap1‑Nrf2 signaling pathway as a therapeutic target for mitigating SCD complications. My selected publications include "Rpl13a snoRNAs U34 and U35a: New Targets for Sickle Cell Disease Complications" in Circulation Research (2025) and "Keap1‑Nrf2 Heterodimer: A Therapeutic Target to Ameliorate Sickle Cell Disease" in Antioxidants (2023). I carry out my work at UTHSC, collaborating with a team to address the unmet medical needs of patients with sickle cell disease.

Employment

Employment history is unavailable.

Education

• Aligarh Muslim University PhD
  2015 - Present

Projects & Funding

Projects & funding information is unavailable.

Publications

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