0000-0002-9126-6431 About
Ms. Neha Kumari began her academic journey with a Bachelor of Science degree from Jamshedpur Women's College in 2016, followed by an impressive Master of Science achievement at Banasthali Vidyapith in 2018. Neha is pursuing a doctoral degree at BIT Mesra, Ranchi, from 2019 to 2023(continuing), where she developed a compound which shows an antiviral activity.
Neha explained that Viral Diseases continues to be a major global public health threat. Specifically HIV, there were an estimated 38 million people living with HIV at the end of 2019. And we have been able to control AIDS to a great extent and prolong the life of infected individuals, but the fact remains that we are still far from eradicating the disease from human population. Viral Mutation, Drug Resistance and Latency are Serious Concern and HIV is still Non-Curable. HIV-1 is not able to complete its life cycle without host metabolic support. Thus, Targeting Host Factor Such as HSP90 is an alternative novel approach toward a possible cure for HIV. Here, she proposes to target host factor protein HSP90 to design and synthesis of novel drug like molecules and looking forward to contribute for HIV Cure.
Neha also have knowledge of single crystal X-ray crystallography and molecular modeling. She has also worked in collaboration with the biotech engineering department of BIT Mesra to understand the TaARF12's role in gene expression regulation and cellular processes involving DNA interactions. Her main aim is to investigate the structural characteristics and DNA binding properties of TaARF12-DBD, a target protein. A 3D structural model of TaARF12-DBD was constructed and docking simulations revealed the formation of a dimeric complex.
Neha has guided four M.Sc students. Neha seeks to advance scientific understanding, explore novel technologies.
Employment
Employment history is unavailable.
Education
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Birla Institute of Technology, Mesra Ph.D.2019 - 2034
Projects & Funding
Projects & funding information is unavailable.
Publications (8)
- A One-Pot Microwave Green Synthesis of Pyrrolo[1,2-C]Imidazole-1-One Analogs and Structural Studies Save
- Chemo-/Regio-Selective Synthesis of Novel Functionalized Spiro[pyrrolidine-2,3′-oxindoles] under Microwave Irradiation and Their Anticancer Activity Save
- Synthesis, X-ray diffraction and theoretical studies to understand the molecular basis of druglikeness of isoxazole analogs Save
- Amidate ion‐mediated intramolecular ring transformation of 2‐pyrones to 2‐pyridones Save
- Structural Basis for the Understanding of Entry Inhibitors against SARS Viruses Save
- Synthesis and anti-HIV activity of a new isoxazole containing disubstituted 1,2,4-oxadiazoles analogs Save
- Pd-Catalysed [3 + 2]-cycloaddition towards the generation of bioactive bis-heterocycles/identification of COX-2 inhibitors via in silico analysis Save
- Potential Impact of COVID-19 on Female Reproductive Health Save