Dr Boopathi S
SRM Institute of Science and Technology, IIT Madras, Bharathiar University, Jamal Mohamed College, Universidad Nacional Autónoma de México Facultad de Economía
0000-0002-9249-1112
About
I was born on July 30, 1986, in the small town of Mallasamudram, Tamil Nadu, India, into a traditional handloom-weaver family. Growing up in this environment instilled in me the values of perseverance, discipline, and craftsmanship, which later shaped my scientific mindset. Guided by curiosity and determination, I pursued higher studies in physics, earning my B.Sc., M.Sc., M.Phil., and Ph.D. I gradually built a research career dedicated to unraveling the molecular mechanisms of Alzheimer’s disease. Since 2010, my research has focused on the molecular basis of Alzheimer’s disease, particularly the oligomerization of amyloid-β, protein-membrane interactions, and their roles in neurotoxicity. I have published approximately 20 papers in leading international journals and have over eight years of postdoctoral research experience across five countries: South Korea, Poland (as a Marie Curie fellow), Chile, Mexico (at UNAM, a top 100 world-ranked university), and India (at IIT Madras, a top 200 world-ranked university). A major highlight of my work is the rational design of M30, a novel small-molecule inhibitor that blocks amyloid toxicity and restores memory in Alzheimer’s disease models—an exciting candidate for future therapeutics. In addition to my research, I actively engage in science communication, writing in Tamil to bring awareness of neuroscience and brain health to the public.
Employment
-
SRM Institute of Science and Technology Assistant Professor2026 - Present
-
IIT Madras National Postdoctoral Fellow2024 - 2026
-
Universidad Nacional Autónoma de México Facultad de Economía Postdoctoral Scientist2021 - 2023
-
University of Talca Postdoctoral Scientist2019 - 2020
-
Institute of Physics Scientific visit2018 - 2018
-
Sookmyung Women's University Department of Chemistry Postdoctoral Scientist2016 - 2017
Education
-
Bharathiar University PhD2011 - 2016
-
Bharathiar University M.Phil2010 - 2011
-
Jamal Mohamed College M.Sc2007 - 2009
-
Ramakrishna Mission Vidyalaya College of Arts and Science B.Sc2004 - 2007
Projects & Funding
Projects & funding information is unavailable.
Publications (21)
- Herpes Simplex Virus Glycoprotein D Associated with Aβ1–42 Tetramers Mediates Neurotoxicity by Perturbing Neuronal Membrane Integrity: A Molecular Dynamics Simulation Save
- A Small Molecule Impedes the Aβ1–42 Tetramer Neurotoxicity by Preserving Membrane Integrity: Microsecond Multiscale Simulations Save
- Calcium inhibits penetration of Alzheimer's Aβ1–42 monomers into the membrane Save
- Bases moleculares de la enfermedad de Alzheimer Save
- An Overview of Several Inhibitors for Alzheimer’s Disease: Characterization and Failure Save
- The stimulatory effects of intracellular α-synuclein on synaptic transmission are attenuated by 2-octahydroisoquinolin-2(1h)-ylethanamine Save
- Zinc binding promotes greater hydrophobicity in Alzheimer's Aβ42 peptide than copper binding: Molecular dynamics and solvation thermodynamics studies Save
- Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment Save
- Characterization of structural and energetic differences between conformations of the SARS-CoV-2 spike protein Save
- Characterization of a new molecule capable of inhibiting several steps of the amyloid cascade in Alzheimer's disease Save