Chandramani Pathak

About

The major focus of our group is to understand the cell death and inflammatory signaling pathways activated during physiological and pathological conditions. Programmed cell death (apoptosis) is a physiological process that is responsible for removal of unwanted cells during embryonic development, tissue homeostasis, immune cell maturation and elimination of pathogen infected cells. Dysregulation of apoptosis leads to many diseases like neurodegeneration, cancer, inflammatory and metabolic disorders. The research group is focusing to unravel molecular mechanism and cross talk between apoptotic and inflammatory signaling in cancer. It is important to explore possible molecular mechanism and find out cellular targets to regulate critical regulators of cell death to induce apoptosis in cancer cells by modulating the apoptotic signaling which may help to develop potential target for both prevention and therapy. In addition group is also focusing on nanoparticle based drug delivery in cancer cells for intervention of cancer therapy.

Employment

• MGM Institute of Health Sciences Navi Mumbai Professor
  2022 - Present
• Amity University Gurgaon Associate Professor
  2020 - Present
• Indian Institute of Advanced Research Associate Professor & Head
  2009 - 2020

Education

• Jiwaji University Ph.D.
  2002 - 2007

Projects & Funding

Projects & funding information is unavailable.

Publications (40)

• Molecular Perspective on Proteases: Regulation of Programmed Cell Death Signaling, Inflammation and Pathological Outcomes
  Journal of Molecular Pathology 2025 DOI: 10.3390/jmp6040032
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• Insights of Endocytosis Signaling in Health and Disease
  International Journal of Molecular Sciences 2023 DOI: 10.3390/ijms24032971
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• Synthesis, Characterization, and Biological Evaluation of Osmium(IV) Pyrazole Carbothioamide Complexes
  Polycyclic Aromatic Compounds 2022 DOI: 10.1080/10406638.2020.1852581
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• Molecular and cellular paradigms of multidrug resistance in cancer
  Cancer Reports 2022 DOI: 10.1002/cnr2.1291
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• Surface modified PAMAM dendrimers with gallic acid inhibit, cell proliferation, cell migration and inflammatory response to augment apoptotic cell death in human colon carcinoma cells
  Journal of Biomolecular Structure and Dynamics 2021 DOI: 10.1080/07391102.2020.1802344
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• Synthesis, characterization, and biological applications of pyrazole moiety bearing osmium(IV) complexes
  Nucleosides, Nucleotides & Nucleic Acids 2021 DOI: 10.1080/15257770.2021.1921795
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• Tetrazolo[1,5-a]quinoline moiety-based Os(IV) complexes: DNA binding/cleavage, bacteriostatic and photocytotoxicity assay
  Journal of Biomolecular Structure and Dynamics 2021 DOI: 10.1080/07391102.2020.1756912
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• Fluorescence, DNA Interaction and Cytotoxicity Studies of 4,5-Dihydro-1H-Pyrazol-1-Yl Moiety Based Os(IV) Compounds: Synthesis, Characterization and Biological Evaluation
  Journal of Fluorescence 2021 DOI: 10.1007/s10895-020-02657-1
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• Molecular insights of NADPH oxidases and its pathological consequences
  Cell Biochemistry and Function 2021 DOI: 10.1002/cbf.3589
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• AGE-RAGE synergy influences programmed cell death signaling to promote cancer
  Molecular and Cellular Biochemistry 2021 DOI: 10.1007/s11010-020-03928-y
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