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Eunus S. Ali

Also known as: Eunus

University of Kentucky College of Medicine, Northwestern University, Flinders University Medicine Program, Stockholm University

Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Biochemical and Molecular Research · Cancer, Hypoxia, and Metabolism · Glioma Diagnosis and Treatment

ORCID iD 0000-0002-9477-3500
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About

Improving obesity- and cancer-related metabolic dysfunctions by investigating and controlling body’s’ signaling pathways and metabolism has been the focus of Eunus Ali Lab’s research. Using biochemistry and cell biology, he works at the molecular level to identify how to efficiently restore aberrant cellular signaling in cancer, diabetes, aging and neurological diseases. He has published some significant works in this area in several well-ranked journals including Molecular Cell, Science Advances, Nature Communications, Brain, BBA - Molecular Cell Research, Biochemical Journal and AJP - Cell Physiology. Prior to Postdoc with Dr. Issam Ben-Sahra at Northwestern University, his PhD was completed under the supervision of Dr. Greg Barritt at Flinders University, and MS at Stockholm's Arrhenius Laboratory with Dr. Göran Widmalm.

His research team is currently pursuing several major lines of metabolic research:

Research Focus #1: Obesity and Diabetes: One of the major lines of research in the lab is to elucidate the molecular and cellular Ca2+-dependent mechanisms underlying obesity, type-2 diabetes and obesity-associated cancers, with the goal of translating the findings into next-generation therapeutics.

Research Focus #2: Cellular Metabolism: Employing high resolution mass spectrometry, biochemical approaches and genome editing CRISPR, Eunus identified two important mechanisms in cell metabolism - in response to growth or oncogenic signals, how cells increase nucleotide metabolism to boost their cell proliferation. Both studies have separately been published in Molecular Cell. Further, two additional projects related to cellular nucleotide, and lipid metabolism are being conducted in the lab.

As an Assistant Professor, Eunus currently directs 'Laboratory for Cellular and Cancer Metabolism' in the Department of Toxicology and Cancer Biology, and the Markey Cancer Center. He is also a member of the Center for Cancer and Metabolism, and Barnstable Brown Diabetes and Obesity Center in the University of Kentucky College of Medicine. The overview of current research program can be found in the lab website:

https://eal-metabolab.com/

Employment

  • University of Kentucky College of Medicine Assistant Professor
    2024 - Present

Education

  • Northwestern University Postdoc
    ? - 2024
  • Flinders University Medicine Program Ph.D.
    ? - 2017
  • Stockholm University M.S.
    ? - 2011

Projects & Funding

Projects & funding information is unavailable.

Publications (31)