MW
Mark Wilkes
Stanford University, James Cook University
Research areas: Medicine · Hematology · Blood disorders and treatments · TGF-β signaling in diseases · Hematopoietic Stem Cell Transplantation
0000-0002-9600-6831
Employment
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Stanford University School of Medicine Instructor2020 - Present
Education
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James Cook University Doctor of Philosophy2012 - 2016
Projects & Funding
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Characterization of the Role of Nemo-like Kinase in Normal and Diamond Blackfan Anemia Models of Erythropoiesis. National Institute of Diabetes and Digestive and Kidney Diseases2021 - 2026
Publications (40)
- Exosomal miR-26a delivery increases erythroid expansion in models of Diamond-Blackfan anemia Save
- Small molecule OTS167 increases erythropoiesis and improves anemia in diamond blackfan anemia models in vitro and In Vivo Save
- Activation of Nemo-like Kinase in Diamond Blackfan Anemia suppresses early erythropoiesis by preventing mitochondrial biogenesis. Save
- Novel Mouse Model That Recapitulates the Hematologic Phenotype of Diamond Blackfan Anemia Save
- Small Molecule Inhibitor Targeting Nemo-like Kinase Improves Erythropoiesis in Human and Mouse Models of Diamond Blackfan Anemia Save
- SATB1 chromatin loops regulate Megakaryocyte/Erythroid Progenitor Expansion by facilitating HSP70 and GATA1 induction. Save
- Animal models of Diamond-Blackfan anemia: updates and challenges. Save
- Downregulation of SATB1 by miRNAs reduces megakaryocyte/erythroid progenitor expansion in preclinical models of Diamond–Blackfan anemia Save
- Nutritional Supplements, Ginseng and Leucine, Increase Erythropoiesis in Diamond Blackfan Anemia Models through Inhibition of Nemo-like Kinase Save
- SATB1 Regulates Chromatin Organization and HSP70 Expression in Early Erythropoiesis and Is Downregulated in Models of Diamond Blackfan Anemia Save
- The Serine Threonine Kinase Inhibitor Ots-167 Improves Erythropoiesis through Suppression of Nlk Activity in Diamond Blackfan Anemia Models Save
- Signaling Pathways That Regulate Normal and Aberrant Red Blood Cell Development. Save
- The active component of ginseng, ginsenoside Rb1, improves erythropoiesis in models of Diamond-Blackfan anemia by targeting Nemo-like kinase. Save
- Metformin-induced suppression of Nemo-like kinase improves erythropoiesis in preclinical models of Diamond-Blackfan anemia through induction of miR-26a. Save
- Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase Save
- MMP9 inhibition increases erythropoiesis in RPS14-deficient del(5q) MDS models through suppression of TGF-β pathways. Save
- INHIBITION OF NEMO-LIKE KINASE IMPROVES ERYTHROPOIESIS IN MODELS OF DIAMOND BLACKFAN ANEMIA Save
- Chromatin Organization By SATB1 Regulates HSP70 Induction in Early Erythropoiesis and Lost in Diamond Blackfan Anemia Save
- MMP9 Inhibition Rescues the Erythroid Defect in RPS14-Deficient Del(5q) MDS Models Save
- Pharmacological Inhibition of Nlk (Nemo-like Kinase) Rescues Erythropoietic Defects in Pre-Clinical Models of Diamond Blackfan Anemia Save