Raj Kumar
Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organisation, Indian Institute of Technology Roorkee
0000-0002-9702-2788
About
I joined the Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO in the year 2001 just after completing my Ph.D. in biotechnology from the Indian Institute of Technology, Roorkee. INMAS is a premier institution that worked in the area of radiation countermeasure development. I start learning about radioprotection and its importance, its national and international importance, etc. During the initial phase of my learning, I thought about radioresistant bacteria and their possible applications in the area of radioprotector development. I discussed my interest with INMAS director Dr. R.P Tripathi. He not only appreciates my logic but rather gave me a task project to initiate work in this novel area in the year 2005. since then I involved in the same area and achieved several milestones. As a result of the continuous support from my organization, I have identified the bioactive bacterial molecules that provide excellent radioprotection to the cells, mice, and Non-human primates (Monkey). This molecule has been qualified for its regulatory toxicity/safety profile, stable and efficacious human usable formulation, pharmacokinetics studies, pharmaceutical targets, and efficacy biomarker and validation studies. This molecule may be the first Indian molecule that will reach the IND status and emergency use approval from the regulatory authorities of India. Recently we received a new grant from my organization (DRDO) to conduct all regulatory studies and get the IND status for this molecule. Hopefully, we will be successful in this endeavor in near future.
Employment
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Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organisation Scientist-F2001 - 2031
Education
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Indian Institute of Technology Roorkee Ph.D.1995 - 2000
Projects & Funding
Projects & funding information is unavailable.
Publications (109)
- N-acetyl-L-tryptophan provides radioprotection to mouse and primate models by antagonizing the TRPV1 receptor and substance P inhibition Save
- Emerging implications of bacterial biofilm in cancer biology: Recent updates and major perspectives Save
- N-acetyl-L-tryptophan (NAT) provides protection to intestinal epithelial cells (IEC-6) against radiation-induced apoptosis via modulation of oxidative stress and mitochondrial membrane integrity Save
- Amelioration of Radiation‐Induced Cell Death in Neuro2a Cells by Neutralizing Oxidative Stress and Reducing Mitochondrial Dysfunction Using N‐Acetyl‐L‐Tryptophan Save
- Amelioration of radiation-induced cell death in Neuro2a cells by neutralizing oxidative stress and reducing mitochondrial dysfunction using N-acetyl-L-tryptophan, Save
- Antibiofilm activities of biogenic silver nanoparticles against Candida Albicans Save
- In-vitro alleviation of ochratoxin a mediated cytotoxicity using N-acetyl-L-tryptophan glucoside pretreatment Save
- Modulation of radiation-induced intestinal injury by radioprotective agents: a cellular and molecular perspectives Save
- Synthesis, purification and characterization of Plectonema derived AgNPs with elucidation of the role of protein in nanoparticle stabilization Save
- Biomedical potential of Anabaena variabilis NCCU 441 based Selenium nanoparticles and their comparison with commercial nanoparticles. Save