Venkatesan Jayaprakash
Birla Institute of Technology, Mesra, Birla Institute of Technology, University of Hyderabad, Institute of Technology Banaras Hindu University
0000-0002-9724-4153
About
Basically a synthetic medicinal chemist, completed PhD in Pharmacy from Birla Institute of Technology in the Title "Design, Synthesis and Pharmacological Screening of Mycobactin Analogues"
Area of interest includes Molecular modeling and drug design and synthesis of small molecule heterocycles against targets of therapeutical importance. Molecular modeling includes Structure Based Drug Design (SBDD), Fragment Based Drug Design (FBDD), High-throughput Virtual Screening (HTVS) and Molecular Dynamics (MD). Targets under investigation are (i) Biosynthetic enzymes in the pathway of Mycobactin synthesis-target for anti-tubercular drug design; (ii) Histone deacetylase and Ribonucleotide-anti-cancer; (iii) protease, methyl-transferase & E-protein-anti-viral and (iv) MAO-neurodegenerative disorder. Chemical scaffolds designed: pyrazolines, aminothiazoles, thiosemicarbazones and piperazines.
Employment
-
Birla Institute of Technology, Mesra Professor2021 - Present
-
Birla Institute of Technology Associate Professor2016 - 2021
-
Birla Institute of Technology Assistant Professor2007 - 2016
-
Birla Institute of Technology Lecturer2004 - 2007
Education
-
Birla Institute of Technology, Mesra Ph. D.2005 - 2012
-
University of Hyderabad PGDCAQM2003 - 2004
-
Institute of Technology Banaras Hindu University M. Pharmacy1997 - 1999
-
Madras Medical College Bachelor of Pharmacy1993 - 1996
-
Coimbatore Medical College D. Pharmacy1991 - 1992
Projects & Funding
Projects & funding information is unavailable.
Publications (110)
- Quinolinequinone-based sulfonamide bioisosteres as promising antimicrobial agents Save
- INTEGRATED BIOANALYTICAL METHOD VALIDATION, PHARMACOKINETICS, AND METABOLITE CHARACTERIZATION OF 19‑MONOAMINOTHIAZOLE (19MAT): A CORRELATIVE IN‑SILICO AND IN‑VIVO STUDY USING LC–MS/MS Save
- Aminated Quinolinequinones With EDG(s) as a Prostate Cancer Inhibitor: Mechanistic Insights and Pharmacokinetic Limitations Save
- Exploring isoquinolinequinones as promising antibacterial agents against methicillin-resistant Staphylococcus strains: synergistic effects with clinical antibiotics and antibiofilm activity Save
- Reimagining QSAR Modeling with Quantum Chemistry: A CYP1B1 Inhibitor Case Study Save
- Repurposing FDA-Approved Drugs as Potential Inhibitors of MbtB for Tuberculosis Therapy Save
- Identification of novel thiazole derivatives as flaviviral protease inhibitors effective against Dengue (DENV2) and Japanese encephalitis viruses Save
- Advancements in the design and development of pyrazoline-based antimycobacterial agents: an update and future perspectives Save
- Identification of novel thiazole derivatives as flaviviral protease inhibitors against DENV and JEV Save
- Prospects for Prostate Cancer Chemotherapy: Cytotoxic Evaluation and Mechanistic Insights of Quinolinequinones with ADME/PK Profile Save