KB
Kelly Brooks
QIMR Berghofer Medical Research Institute, Cancer Research UK Manchester Institute, The University of Queensland
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Melanoma and MAPK Pathways · Cutaneous Melanoma Detection and Management · Cancer Genomics and Diagnostics
0000-0002-9751-5961
Employment
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QIMR Berghofer Medical Research Institute Research Officer2017 - Present
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Cancer Research UK Manchester Institute Postdoctoral Scientist2012 - 2016
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University of Queensland Research Assistant2012 - 2012
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University of Queensland Research Assistant2007 - 2008
Education
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University of Queensland Ph.D in Cancer Biology2008 - 2012
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University of Queensland Bachelor of Science Honours Class I2007 - 2007
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University of Queensland Bachelor of Science2004 - 2006
Projects & Funding
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Dissecting uveal melanoma biology and microenvironment through single cell anlayses The Kiersznowski Family Charitable Trust2022 - 2022
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Investigating PARP inhibitors for the treatment of SF3B1 mutant melanoma Cure Cancer Australia2020 - 2022
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Characterising and targeting PLCB4 mutations in uveal melanoma Cancer Australia2018 - 2020
Publications (23)
- Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes. Save
- Choroidal melanoma with synchronous Fuchs' adenoma and novel ATRX mutation. Save
- Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma. Save
- Definition of Biologically Distinct Groups of Conjunctival Melanomas According to Etiological Factors and Implications for Precision Medicine. Save
- Ultraviolet radiation drives mutations in a subset of mucosal melanomas. Save
- A rare missense variant in protection of telomeres 1 (POT1) predisposes to a range of haematological malignancies. Save
- Loss-of-function variants in POT1 predispose to uveal melanoma. Save
- Genomic analysis of adult case of ocular surface giant congenital melanocytic nevus and associated clinicopathological findings. Save
- Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours. Save
- Germline variants in oculocutaneous albinism genes and predisposition to familial cutaneous melanoma. Save
- Prolonged stable disease in a uveal melanoma patient with germline MBD4 nonsense mutation treated with pembrolizumab and ipilimumab. Save
- A novel ATM-dependent checkpoint defect distinct from loss of function mutation promotes genomic instability in melanoma Save
- Simultaneous inactivation of TP53 and loss of PTEN diminish response to targeted therapy in V600EBRAF mutant melanoma Save
- Decatenation checkpoint-defective melanomas are dependent on PI3K for survival Save
- Defective Decatenation Checkpoint Function Is a Common Feature of Melanoma Save
- A potent Chkl inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress Save
- Chk1 inhibitor targets replicative stress in melanomas. Save
- Defective cell cycle checkpoints as targets for anti-cancer therapies Save
- Keeping replicative stress in Chk Save
- A DNA damage checkpoint response to unrepaired ultraviolet radiation induced lesions which is defective in melanoma Save