Tania Vane-Tempest

About

Tania Vane‑Tempest is a postdoctoral researcher at the University of Helsinki's Institute of Biotechnology. She has a background in molecular virology, with a focus on RNA virus replication and virus–host interactions. She completed her PhD in 2019, studying viral replicase proteins, and has contributed to research on alphaviruses. After her PhD, she worked as a postdoctoral researcher in Belgium before returning to Finland, where she contributed to studies on SARS‑CoV‑2. Since 2024, she has been part of the Business Finland–funded MITOGUARDER project, which aims to improve cellular systems for biologics production.

Employment

• University of Helsinki Principal Scientist
  2024 - Present
• University of Helsinki Postdoctoral researcher
  2023 - 2024
• Université Libre de Bruxelles Postdoctoral researcher
  2020 - 2022
• University of Helsinki PhD student
  2014 - 2019
• Laboratoire Médical Des Villes Soeurs Medical Laboratory Technician
  2007 - 2010

Education

• Vrije Universiteit Amsterdam MSc Biomolecular Sciences
  2010 - 2012
• University of Mauritius BSc (Hons) Biomedical Sciences
  2004 - 2008

Projects & Funding

• Replicase Proteins Under Scrutiny: Trans-Replication Systems to Dissect RNA Virus Replication Alfred Kordelinin Säätiö
  2018 - 2019
• Replicase Proteins Under Scrutiny: Trans-Replication Systems to Dissect RNA Virus Replication Suomalainen Tiedeakatemia
  2016 - 2017
• Replicase Proteins Under Scrutiny: Trans-Replication Systems to Dissect RNA Virus Replication Helsingin Yliopisto
  2016 - 2017
• MSc Biomolecular Sciences Vrije Universiteit Amsterdam
  2010 - 2012
• BSc (Hons) Biomedical Sciences University of Mauritius
  2008 - 2008

Publications (10)

• SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes accumulation of HIF1ɑ and phosphorylated tau
  2024 DOI: 10.1101/2024.11.21.624622
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• Dynamin independent endocytosis is an alternative cell entry mechanism for multiple animal viruses.
  PLoS pathogens 2024 DOI: 10.1371/journal.ppat.1012690
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• Clinical and genetic delineation of autosomal recessive and dominant ACTL6B-related developmental brain disorders.
  Elisa Calì, Tania Quirin, Clarissa Rocca +97 more
  Genetics in medicine : official journal of the American College of Medical Genetics 2024 DOI: 10.1016/j.gim.2024.101251
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• Inhibition of host N-myristoylation compromises the infectivity of SARS-CoV-2 due to Golgi-bypassing egress from lysosomes and endoplasmic reticulum
  2023 DOI: 10.1101/2023.03.03.530798
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• Macrodomain Binding Compound MRS 2578 Inhibits Alphavirus Replication.
  Antimicrobial agents and chemotherapy 2021 DOI: 10.1128/aac.01398-21
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• The RNA Capping Enzyme Domain in Protein A is Essential for Flock House Virus Replication
  Viruses 2018 DOI: 10.3390/v10090483
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• Partially Uncleaved Alphavirus Replicase Forms Spherule Structures in the Presence and Absence of RNA Template
  Journal of Virology 2017 DOI: 10.1128/jvi.00787-17
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• Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue
  Scientific Reports 2016 DOI: 10.1038/srep37124
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• Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein
  2016
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• Comparative contamination rate of toys in kindergartens and households
  2012
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