Hiromitsu Nakauchi

About

Dr. Hiromitsu (Hiro) Nakauchi is recognized as a pioneer in the field of stem cell research and single cell biology. He demonstrated that a single hematopoietic stem cell (HSC) can reconstitute the entire blood-lymphatic system of irradiated (HSC-removed) mice, a definitive proof for “stemness”. After years of research, his laboratory successfully developed the method to expanded functional HSCs ex vivo. This achievement offers a culture platform for broad applications for HSC biology and notable translational implications.
His experience in HSC research led to the idea of “organ niche” and successfully created a rat pancreas in mice, a groundbreaking demonstration of cross-species organogenesis. His research focuses on linking discoveries in stem cell biology, immunology, molecular biology, and developmental engineering to effective stem cell therapies.

Employment

• Institute of Science Tokyo Distinguished University Professor
  2022 - Present
• The Institute of Medical Science, The University of Tokyo Project Professor
  2017 - 2022
• Stanford University School of Medicine Professor
  2014 - Present
• The Institute of Medical Science, The University of Tokyo Professor
  2002 - 2017
• Institute of Medical Sciences, University of Tsukuba Professor
  1993 - 2002

Education

• The University of Tokyo Ph.D.
  1979 - 1983
• Yokohama City University MD
  1971 - 1978

Projects & Funding

Projects & funding information is unavailable.

Publications (50)

• Generation of heterozygous PKD1 mutant pigs exhibiting early-onset renal cyst formation.
  Laboratory investigation; a journal of technical methods and pathology 2022 DOI: 10.1038/s41374-021-00717-z
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• An optimized Sendai viral vector platform for reprogramming to naive pluripotency.
  Cell reports methods 2022 DOI: 10.1016/j.crmeth.2022.100349
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• Treatment of a genetic brain disease by CNS-wide microglia replacement.
  Science translational medicine 2022 DOI: 10.1126/scitranslmed.abl9945
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• Generation of Tfap2c-T2A-tdTomato knock-in reporter rats via adeno-associated virus-mediated efficient gene targeting.
  Molecular reproduction and development 2022 DOI: 10.1002/mrd.23562
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• Xenotransplantation and interspecies organogenesis: current status and issues.
  Frontiers in endocrinology 2022 DOI: 10.3389/fendo.2022.963282
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• METABOLIC PROFILING OF MOUSE HEMATOPOIETIC STEM CELL SELF-RENEWAL AT SINGLE-CELL RESOLUTION
  2022
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• DEVELOPMENT OF EX VIVO HEMATOPOIETIC STEM CELL ASSAYS USING A HIGHLY SELECTIVE EXPANSION SYSTEM
  2022
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• Bioluminescent Tracking of Human Induced Pluripotent Stem Cells In Vitro and In Vivo.
  Methods in molecular biology (Clifton, N.J.) 2022 DOI: 10.1007/978-1-0716-2453-1_22
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• Advances in Allogeneic Cancer Cell Therapy and Future Perspectives on "Off-the-Shelf" T Cell Therapy Using iPSC Technology and Gene Editing.
  Cells 2022 DOI: 10.3390/cells11020269
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• Investigation of Cas9 antibodies in the human eye.
  Nature communications 2022 DOI: 10.1038/s41467-022-28674-1
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