Sumana Ghosh

About

Fifteen+ years experience in medicinal chemistry, organic chemistry, drug discovery, and patent analysis. Strong background in strategic planning and executing drug discovery project starting from in silico design of new structural scaffolds, AI platform to predict ADME and toxicity profile, Hit identification, Hit to Lead optimisation till pre-clinical development.
10 years experience in new antibiotic drug discovery program and published scientific findings in many peer-reviewed journals (https://pubmed.ncbi.nlm.nih.gov/36229662/) and patents (fifteen granted global patent applications in the areas of Medicinal Chemistry)
2.5 years experience in new drug discovery in oncology and precision medicine.
Highly creative and experienced in leading and motivating team with high integrity. Energetic leader with proven skills in delivering project within stipulated time.

Employment

• Capulus Therapeutics LLC Head of Discovery
  2020 - Present
• Vyome Biosciences (India) Associate Director
  2010 - 2020

Education

• Université Joseph Fourier Post doctoral Associate
  2007 - 2008
• Indian Institute of Science Bangalore PhD
  2002 - 2006

Projects & Funding

Projects & funding information is unavailable.

Publications (20)

• A potent antibiotic-loaded bone-cement implant against staphylococcal bone infections.
  Nature biomedical engineering 2022 DOI: 10.1038/s41551-022-00950-x
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• Mechanistic Insight Into the Antifungal Effects of a Fatty Acid Derivative Against Drug-Resistant Fungal Infections
  Frontiers in Microbiology 2020 DOI: 10.3389/fmicb.2020.02116
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• A Rationally Designed Multifunctional Antibiotic for the Treatment of Drug-Resistant Acne
  Journal of Investigative Dermatology 2018 DOI: 10.1016/j.jid.2017.11.041
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• Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus
  ACS Chemical Biology 2013 DOI: 10.1021/cb400612h
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• Modeling Nonaqueous Proton Wires Built from Helical Peptides: Biased Proton Transfer Driven by Helical Dipoles
  The Journal of Physical Chemistry A 2012 DOI: 10.1021/jp210208m
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• Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface
  Biopolymers 2012 DOI: 10.1002/bip.22080
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• Controlled Density Patterning of Tolylterpyridine-Tagged Oligonucleotides
  Langmuir 2011 DOI: 10.1021/la2003468
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• Metal-Complex/DNA Conjugates: A Versatile Building Block for DNA Nanoarrays
  Chemistry - A European Journal 2010 DOI: 10.1002/chem.201001590
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• Oligonucleotide Duplexes with Tethered Photoreactive Ruthenium(II) Complexes: Influence of the Ligands and Their Linker on the Photoinduced Electron Transfer and Crosslinking Processes of the Two Strands
  European Journal of Inorganic Chemistry 2009 DOI: 10.1002/ejic.200801083
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• Design and synthesis of novel hybrid metal complex–DNA conjugates: key building blocks for multimetallic linear DNA nanoarrays
  Organic & Biomolecular Chemistry 2009 DOI: 10.1039/b904758a
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