Matteo Zampini
IRCCS Humanitas Research Hospital, Fondazione Città della Speranza, University of Padua
Research areas: Medicine · Hematology · Acute Myeloid Leukemia Research · Retinoids in leukemia and cellular processes · Artificial Intelligence in Healthcare and Education
0000-0002-9952-1142
About
I am a highly experienced researcher with a PhD in Bioscience and Biotechnology from the University of Padova in 2014.
I currently work at the Laboratorio di Genomica delle Neoplasie Ematologiche of the IRCCS Humanitas Research Institute & Humanitas University in Milan, Italy. I am an expert in molecular biology, sequencing, and computational biology.
I am carrying out different projects regarding bioinformatics analyses in Myelodysplastic Syndromes (MDS) to understand their genomic basis, to identify new prognostic scores and to develop personalized treatments.
I dedicated my academic and professional career to studying cancer biomarkers and deregulated oncogenic pathways using integration of genomics, transcriptomics and epigenetics data and techniques (microarrays, NGS, single-cell sequencing). In particular I focused my research in the production and bioinformatics analysis of high-throughput sequencing data in Malignant Melanoma, Acute Myeloid Leukemia and Myelodysplastic Syndromes. During my career, I have supervised several students and PhD students in organizing and discussing their scientific projects.
I have held various research fellowships, including positions at IOV (Istituto Oncologico Veneto), Biology of Pediatric Solid Tumors Laboratory in Padova University, Istituto di Ricerca Pediatrica – Fondazione Città della Speranza, and IRCCS Humanitas Research Institute.
I have also published numerous articles in haematology leading journals, including Leukemia, Blood, Journal of Clinical Oncology, Lancet Haematology.
Employment
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IRCCS Humanitas Research Hospital postdoctoral research fellow (next generation sequencing- NGS of acute myeloid leukemia and other myeloid neoplasms, NGS data analysis pipelines)2018 - Present
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Fondazione Città della Speranza postdoctoral research fellow (Bioinformatics analyses in Acute Myeloid Leukemia high-throughput data)2014 - 2017
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Università degli Studi di Padova Research fellowship (Functional study and clinical implications of genes, miRNA and methylated regions differentially expressed in rhabdomyosarcoma)2012 - 2014
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Istituto Oncologico Veneto Istituto di Ricovero e Cura a Carattere Scientifico Research fellowship (role of oncomiRNAs in Soft Tissue Sarcoma pathogenesis)2009 - 2012
Education
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Università degli Studi di Padova Biotechnology and Biosciences PhD School2010 - 2014
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Università degli Studi di Padova Master’s Degree in Industrial Biotechnology2006 - 2008
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Università degli Studi di Padova Bachelor’s Degree in Biotechnology2003 - 2006
Projects & Funding
Projects & funding information is unavailable.
Publications (20)
- PU.1-activated genomic regions define low-risk MDS subsets characterized by immune dysregulation and disease progression Save
- Characterization and Clinical Implications of p53 Dysfunction in Patients With Myelodysplastic Syndromes Save
- Translational Research on Azacitidine Post-Remission Therapy of Acute Myeloid Leukemia in Elderly Patients (QOL-ONE Trans-2) Save
- Translational Research on Azacitidine Post- Remission Therapy of Acute Myeloid Leukemia in Elderly Patients (QOL-ONE Trans-2) Save
- Clinical and Genomic-Based Decision Support System to Define the Optimal Timing of Allogeneic Hematopoietic Stem-Cell Transplantation in Patients With Myelodysplastic Syndromes Save
- Synthetic Data Generation by Artificial Intelligence to Accelerate Research and Precision Medicine in Hematology Save
- Real-World Validation of Molecular International Prognostic Scoring System for Myelodysplastic Syndromes Save
- A sex-informed approach to improve the personalised decision making process in myelodysplastic syndromes: a multicentre, observational cohort study Save
- The Genetics of Myelodysplastic Syndromes: Clinical Relevance Save
- Clinical relevance of clonal hematopoiesis in the oldest-old population Save
- Classification and Personalized Prognostic Assessment on the Basis of Clinical and Genomic Features in Myelodysplastic Syndromes Save
- Clinical Relevance of Clonal Hematopoiesis in the Oldest-Old Population Save
- Epigenetic heterogeneity affects the risk of relapse in children with t(8;21)RUNX1-RUNX1T1-rearranged AML. Save
- A three-miRNA-based expression signature at diagnosis can predict occurrence of relapse in children with t(8;21) RUNX1-RUNX1T1 acute myeloid leukaemia. Save
- The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia. Save
- NUP98-fusion transcripts characterize different biological entities within acute myeloid leukemia: a report from the AIEOP-AML group. Save
- Characterization of children with FLT3-ITD acute myeloid leukemia: a report from the AIEOP AML-2002 study group. Save
- CREB engages C/EBPδ to initiate leukemogenesis. Save
- MicroRNA-27a Contributes to Rhabdomyosarcoma Cell Proliferation by Suppressing RARA and RXRA. Save
- miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1. Save