Marcella Martin
Also known as: Marcy Martin
University of Zurich, Stanford University, University of California, Riverside, University of California, Santa Cruz, University of California San Diego
Research areas: Medicine · Surgery · Tissue Engineering and Regenerative Medicine · Atherosclerosis and Cardiovascular Diseases · Pluripotent Stem Cells Research
0000-0003-0035-0185
About
Molecular biologist and bioengineer driven to translate innovative treatment solutions to patients with limited curative therapies available. Highly experienced modeling human cardiovascular diseases, such as cardiomyopathies, pulmonary fibrosis, and atherosclerosis using stem cell-derived 2D cultures or 3D multicellular organoids in vitro, as well as utilizing mouse models to mimic disease in vivo. Expertise in iPSC biology, automated liquid handling systems, multi-color microscopy, primary human and mouse tissue processing, high throughput systems biology approaches including RNA-seq, scRNA-seq, ChIP-seq, ATAC-seq, cell-based biochemical activity assays, and immunological/histological analyses. Effective in leading interdisciplinary and international collaborative projects as demonstrated by a multitude of high impact publications.
Employment
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University of Zurich Group Leader2021 - Present
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Stanford University Postdoctoral Fellow2019 - 2021
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UC San Diego PhD Graduate Student2013 - 2018
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Santa Cruz Biotechnology Inc Department Head2009 - 2012
Education
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UC Riverside PhD2012 - 2017
- 2005 - 2009
Projects & Funding
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Mechanisms and Innovations in Cardiovascular Disease Postdoctoral Training Grant NIH Clinical Center2019 - 2021
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SREBP2-Induced EndoMT Contributing to Pulmonary Arterial Hypertension American Lung Association2018 - 2019
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Cardiovascular Physiology and Pharmacology Pre-Doctoral Training Grant NIH Clinical Center2015 - 2016
Publications (24)
- Apoptosis as a strategy for enhancing decellularization and remodeling of tissue-engineered heart valves Save
- Combining genome and tissue engineering for next-generation human biomimetics Save
- Modulating biomechanical and integrating biochemical cues to foster adaptive remodeling of tissue engineered matrices for cardiovascular implants Save
- Advances in 3D Organoid Models for Stem Cell-Based Cardiac Regeneration Save
- Have we found the missing link between inflammation, fibrosis, and calcification in calcific aortic valve disease? Save
- Combining Cell Technologies With Biomimetic Tissue Engineering Applications: A New Paradigm for Translational Cardiovascular Therapies. Save
- Macrophage-extracellular matrix interactions: Perspectives for tissue engineered heart valve remodeling Save
- Role of endothelial cells in pulmonary fibrosis via SREBP2 activation. Save
- Human iPSCs and Genome Editing Technologies for Precision Cardiovascular Tissue Engineering. Save
- Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome. Save
- Endothelial mechanobiology Save
- Shear stress regulation of miR-93 and miR-484 maturation through nucleolin. Save
- Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications. Save
- AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension. Save
- Short-Term High-Salt Diet Increases Corin Level to Regulate the Salt-Water Balance in Humans and Rodents. Save
- Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility. Save
- MicroRNA-92a Mediates Endothelial Dysfunction in CKD. Save
- AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1. Save
- TIFA as a crucial mediator for NLRP3 inflammasome. Save
- miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease. Save