Ashutosh Singh
The University of Texas MD Anderson Cancer Center Children's Cancer Hospital, Indian Institute of Technology Mandi, Hemwati Nandan Bahuguna Garhwal University
0000-0003-0193-9346
About
I am a dedicated cancer research scientist currently in my fifth year of postdoctoral training, specializing in pediatric neuro-oncology and molecular biology. My research is centered on understanding the complex signaling pathways in Sonic Hedgehog (SHH) medulloblastoma and the functional role of deubiquitinating enzymes like USP37. I am honored to have been awarded a prestigious American Cancer Society Postdoctoral Fellowship, which currently supports my research investigating the VHL tumor suppressor in medulloblastoma, as well as evaluating different promising combinatorial therapies in vivo using intracranial orthotopic medulloblastoma models.
I earned my Ph.D. from the Indian Institute of Technology Mandi, where my research was dedicated to the discovery of novel inhibitor molecules targeting c-Myc, a protein widely considered "undruggable" in cancer therapy. I am currently conducting my postdoctoral research at the MD Anderson Cancer Center, where I integrate advanced in vivo models with comprehensive computational and molecular techniques. My methodology spans diverse disciplines, including bulk RNA sequencing, single-cell transcriptomics, spatial transcriptomics using the 10x Genomics Visium HD platform, and detailed histological analysis. My laboratory expertise also encompasses cellular bioenergetic analysis using Seahorse XF assays, alongside molecular techniques such as ChIP-qPCR, Western blotting, and immunocytochemistry.
Beyond my experimental work, I am deeply committed to advancing the field as a peer reviewer for multiple scientific journals and as a Guest Editor. As I advance in my career, I am now applying for tenure-track Assistant Professor positions to continue investigating the molecular drivers of pediatric brain tumors and to lead my own independent research program.
Employment
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The University of Texas MD Anderson Cancer Center Children's Cancer Hospital Postdoctoral Fellow2022 - Present
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Indian Institute of Technology Mandi Project Associate II2021 - 2022
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Indian Institute of Technology Mandi Ph.D. Scholar2016 - 2021
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Zoological Survey of India Northern Regional Centre Research Fellow2012 - 2015
Education
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Hemwati Nandan Bahuguna Garhwal University M.Sc2009 - 2011
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Hemwati Nandan Bahuguna Garhwal University B.Sc2006 - 2009
Projects & Funding
Projects & funding information is unavailable.
Publications (46)
- REST-AKT-SOX2 axis controls neuronal lineage state and Midkine-mediated communication in SHH-medulloblastoma Save
- Identification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells Save
- REST elevation-dependent chromatin remodeling and alternative Grk6 transcript synthesis hyperactivates Cxcr4-Sdf1 signaling in cerebellar granule cell progenitors Save
- Identification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells Save
- REST-dependent downregulation of von Hippel-Lindau tumor suppressor promotes autophagy in SHH-medulloblastoma Save
- Anticancer SAR establishment and α/β-tubulin isoform specific targeting: a detailed insight of the anticancer potential of 4H-chromene derivatives Save
- Functional inhibition of c-Myc using novel inhibitors identified through “hot spot” targeting. Save
- Advancement of Single-Cell Sequencing in Medulloblastoma Save
- Cellular experiments to study the inhibition of c-Myc/MAX heterodimerization Save
- Drug Screening Assays on Medulloblastoma Stem Cells Using Compound Libraries Save