Rajan Vyas

About

My research interest includes the use of X-ray crystallography as a major technique to determine the structure and function of proteins such as membrane proteins, DNA polymerases, and other soluble proteins. The structural studies are coupled to the other biochemical and biophysical methods in order to establish the mechanisms of the respective proteins.

Employment

• Shiv Nadar University Assistant Professor
  2020 - Present
• Central University of Punjab Assistant Professor/Ramalingaswami Fellow
  2018 - 2020
• Case Western Reserve University Postdoctoral Fellow
  2015 - 2017
• Ohio State University Postdoctoral Fellow
  2012 - 2014
• National Institute of Immunology Postdoctoral Fellow
  2010 - 2012

Education

• Panjab University Ph.D
  2004 - 2010

Projects & Funding

Projects & funding information is unavailable.

Publications (20)

• An Aerobic in Vitro Cell Lysate-based Method for Fe-S Cluster Reconstitution in Recombinant Rv1460 Protein from Mycobacterium tuberculosis H37Rv
  Applied Biochemistry and Biotechnology 2026 DOI: 10.1007/s12010-026-05769-9
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• Unveiling the silent defenders: mycobacterial stress sensors at the forefront to combat tuberculosis
  Critical Reviews in Biotechnology 2025 DOI: 10.1080/07388551.2024.2449367
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• Structural insights into the substrate specificity of SP_0149, the substrate-binding protein of a methionine ABC transporter from Streptococcus pneumoniae
  Acta Crystallographica Section F Structural Biology Communications 2019 DOI: 10.1107/S2053230X19009038
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• The voltage-gated sodium channel pore exhibits conformational flexibility during slow inactivation
  Journal of General Physiology 2018 DOI: 10.1085/jgp.201812118
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• Structural basis for the D-stereoselectivity of human DNA polymerase β
  Nucleic Acids Research 2017 DOI: 10.1093/nar/gkx252
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• Structural Insights into the Post-Chemistry Steps of Nucleotide Incorporation Catalyzed by a DNA Polymerase
  Journal of the American Chemical Society 2017 DOI: 10.1021/jacs.6b11258
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• Crystal structures of Mycobacterium tuberculosis HspAT and ArAT reveal structural basis of their distinct substrate specificities
  Scientific Reports 2016 DOI: 10.1038/srep18880
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• VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease
  Nature Communications 2016 DOI: 10.1038/ncomms12646
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• Mechanistic Basis for the Bypass of a Bulky DNA Adduct Catalyzed by a Y-Family DNA Polymerase
  Journal of the American Chemical Society 2015 DOI: 10.1021/jacs.5b08027
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• Viewing human DNA polymerase β faithfully and unfaithfully bypass an oxidative lesion by time-dependent crystallography
  Journal of the American Chemical Society 2015 DOI: 10.1021/jacs.5b02109
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