UG

Uma S. Gautam

Duke University Health System, Michigan State University, Devi Ahilya Vishwavidyalaya, University of Allahabad, Tulane University

ORCID iD 0000-0003-0326-6325
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About

PhD Microbiologist with 10+ years of specialized expertise in microbial contamination analysis, biofilm characterization, BSL-2/BSL-3 laboratory operations, and translational research. Proven ability to integrate microbiology with materials science, pharmaceutical development, and medical device safety. Experienced in root cause analysis, forensic investigation of microbial failures, antimicrobial efficacy testing, and regulatory compliance. Published author of 19 peer-reviewed publications with demonstrated ability to communicate complex technical findings to diverse audiences, including engineers, legal professionals, and industry stakeholders. Strong problem-solving skills refined through independent research design, cross-functional collaborations, and mentoring of multidisciplinary teams. I have broad research interests in septic nonunion, product testing, tuberculosis (TB) immunology, inflammation, host-directed TB immunotherapy, and TB drugs. I am currently investigating the role of memory B cells in TB using cutting-edge single-cell flow cytometry approach with main aim to isolate antibodies and develop an mRNA-based vaccine for TB. I use an ex-vivo co-culture system to determine cellular and molecular mechanisms of macrophages, T Cells, and B cells in TB. Another area of my research interest is phosphoproteomics to understand how mammalian lung cells, as well as mycobacteria, are modulated in the host niche during TB disease progression. The phosphoproteome could be leveraged to develop a biomarker to detect and monitoring tuberculosis disease. My research work is supported by Duke as part of a TB-based research program.

In my current role at Duke University, I oversee Septic Nonunion Biology of Bone Impairment, Antibody Discovery, and Microbiology Research program. I am responsible for developing new TB projects, assigning and prioritizing work according to the need of a research program, overseeing day-to-day activities related to the development of new Biomolecules (DNA / RNA) for GMP production. The core research units I oversee are collaborative research service components of Regional Biocontainment Laboratory housed in Global Health Research Building of Duke Human Vaccine Institute at Duke University School of Medicine in Durham, NC United States.

Employment

  • Duke University Health System Senior Research Associate and Unit Manager
    2019 - Present
  • Michigan State University Research Associate
    2017 - 2019
  • Tulane University Postdoctoral Fellow
    2011 - 2017
  • All-India Institute of Medical Sciences Senior Research Associate
    2007 - 2011

Education

  • Devi Ahilya Vishwavidyalaya PhD
    2003 - 2007
  • University of Allahabad MS
    1999 - 2001

Projects & Funding

Projects & funding information is unavailable.

Publications (20)