Dr. Ashutosh K. Dash
Also known as: Ashutosh K. Dash
Research areas: Chemistry · Organic Chemistry · Synthesis of Organic Compounds · Synthesis and biological activity · Bioactive Compounds and Antitumor Agents
0000-0003-0511-1458
About
A proficient in Medicinal chemistry/ Organic chemistry/ Basic chemistry/pharmaceutical sciences with an experience of 9 years in research and academic sector. Over the years developed expertise in basic as well as applied research (medicinal/ pharmaceutical chemistry; natural product based medicinal chemistry and carbohydrate chemistry) as an assistant professor and researcher in the Natural Product Chemistry division of CSIR-Indian Institute of Integrative Medicine, (IIIM) Jammu. Have experienced in methodologies in translation research like non-infringing routes for the synthesis of APIs and synthesis of drug active metabolites using green chemistry. In natural product chemistry I have expertise in isolation of secondary metabolites from microbial and plant sources, DOS, semi-synthetic modifications, and medicinal chemistry against specific targets in cancer, diabetics, inflammation, etc. Having a pharmaceutical science educational background, a clear understanding of the subjects beyond research area has been achieved. Expertise in drug development process commencing from synthesizing, optimizing up to its detailed pharmacology. Sincere efforts for synthesizing new drug discovery targeting these vital aspects of cancer and have a good working experience with methodologies in organic chemistry has been achieved. Has published expensively in peer-reviewed journals, also published book chapters with springer and Elsevier publishers. In an academic role, mentoring doctoral research scholar (1 Ph.D.) and M. Pharm students (12 Dissertations) as well as B. Pharm students (30 dissertations). I am imparting my experience in research, mentoring and leadership skills amongst the students of Shoolini University, Solan, HP and teaching them medicinal chemistry.
EDUCATION
Ph.D. (2018) -Pharmaceutical Sciences
Indian Institute of Integrative Medicines, (CSIR), Jammu
Guru Nanak Dev University, Amritsar
Title of Thesis: ‘Diversity Oriented Synthesis of Novel Benzopyran Derivatives and Evaluation of their Pharmacological Properties’ (Registration no. 2013. PhD (BP)-01)
Supervisor: Dr. Debaraj Mukherjee, Senior scientist, IIIM, Jammu, J&K.
M. Pharmacy (Pharmaceutical Chemistry) (2012) – University of Pune (P. R No. 6920110415)
B. Pharmacy (2010) – Biju Patnaik University of Technology, Rourkela, Orissa, India (REGD. NO. 0603267012)
RESEARCH EXPERTISE
Expertise in drug development as well as in basic chemistry. This in details involves all the organic syntheses, purification by recrystallization techniques, all the chromatography methods, NMR, IR, Mass spectroscopy, etc, and its pharmacological evaluation against specific targets.
In pharmaceutical chemistry experienced in Molecular hybridization (MH) technique, used to combine two medicinally important scaffolds such as chromene (different benzopyrans /coumarins /flavones) and dihydropyrimidinone).
Utilized heterogeneous catalyst (SiW (H4W12SiO40), PMo (H3PMo12O40), SiMo (H4SiO4Mo12O36), PW (H3PW12O40)) in organic reactions.
In carbohydrate chemistry synthesis of natural molecule mimicking flavones-C-glycosides and coumarin-C-glycoside modulating traditional carbon-Ferrier rearrangement reaction altering it to one pot Mukaiyama type carbon Ferrier rearrangement reaction. I had developed a new method for the O-arylation of carbohydrates under metal-free conditions using arynes as an aryl source with my other colleagues.
In natural product chemistry, I have isolated different natural molecules such as Flavonoids, xanthones, triterpenes and seccoiridoids from the extracts of 5 different plants including Swertia Angustifolia, Pinus gerardina, etc. Different techniques were used for the isolation such as Morphological/Anatomical Analysis, TLC/HPTLC analysis, HPLC Analysis, GC Analysis, Spectroscopic Methods: NMR/MS/NIR/FT-IR. Molecular Biological Methods. Natural product isolation (various Xanthones, Oleanolic acid, beta-sitosterol, etc.) and semi-synthetic work on Swertia Angustifolia. Recently I have developed Induction of systemic acquired resistance against French bean rust by exogenously applying some natural molecules.
Applying green chemistry I have developed a novel method for the synthesis of various chromene dihydropyrimidinone (CDHPM) molecules using recyclable Fe/Al pillared clay catalyst and studied their pharmacokinetic parameters like aqueous solubility, lipophilicity, P-glycoprotein (P-gp) dependent ATPase activity, permeability, plasma protein binding, red blood cell (RBC) partitioning, metabolic stability in liver microsomes and in-vitro-in-vivo computations. Also studied ligand interaction for those compounds with LYS 218 &GLN 220of NF-kB (PDB: 1NF I) as target protein to study the interaction of DHPMs with the target protein.
Employment
Employment history is unavailable.
Education
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Projects & Funding
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Publications (16)
- Diorganotin(IV) complexes derived from thiazole Schiff bases: synthesis, characterization, antimicrobial and cytotoxic studies Save
- Pinus gerardiana Wallichex. D. Don. -A review Save
- Design, synthesis, anticancer and antioxidant activities of amide linked 1,4-disubstituted 1,2,3-triazoles Save
- A standardized polyherbal preparation POL-6 diminishes alcohol withdrawal anxiety by regulating Gabra1, Gabra2, Gabra3, Gabra4, Gabra5 gene expression of GABAA receptor signaling pathway in rats Save
- A Glimpse into Green Chemistry Practices in the Pharmaceutical Industry Save
- Chemically induced systemic acquired resistance in the inhibition of French bean rust Save
- DL-Valine assisted fabrication of quercetin loaded CuO nanoleaves through microwave irradiation method: Augmentation in its catalytic and antimicrobial efficiencies Save
- Synthesis of aryl ethers of carbohydrates via reaction with arynes: selective O-arylation of trans-vicinal dihydroxyl groups in carbohydrates Save
- Green chemistry appended synthesis, metabolic stability and pharmacokinetic assessment of medicinally important chromene dihydropyrimidinones Save
- Pharmacokinetic evaluation of medicinally important synthetic N,N′ diindolylmethane glucoside: Improved synthesis and metabolic stability Save
- Synthesis and investigation of the role of benzopyran dihydropyrimidinone hybrids in cell proliferation, migration and tumor growth Save
- The chemical constituents and diverse pharmacological importance of Tinospora cordifolia Save
- One-pot Mukaiyama type carbon-Ferrier rearrangement of glycals: Application in the synthesis of chromanone 3-C-glycosides Save
- Synthesis of macrolide natural products from carbohydrates Save
- Advances in C-alkynylation of sugars and its application in organic synthesis Save
- Tandem gem–dichlorination and nitrile oxide generation from chlorochromene aldoximes: synthesis of a new class of room temperature fluxional 4-chromanone derivatives Save