SAYAN KUNDU

About

Sayan's research focuses on glycobiology, glycoproteomics, extracellular vesicles, and glycan-mediated cell signaling. I develop chemical, proteomic, and cell biology tools to investigate the roles of cell surface glycans and glycosylation pathways in intercellular communication, cancer biology, and biomarker discovery.

During my Ph.D. at the University of Florida, Sayan developed innovative platforms for glycan labeling, glycolipid-protein interaction studies, and extracellular vesicle glycoengineering. Sayan's current work combines chemical proteomics, mass spectrometry, and glycoproteomics to study glycosyltransferase signaling pathways and to identify tissue-specific glycan biomarkers.
My broader research interests include glycan-based therapeutics, extracellular vesicle engineering, biomarker discovery, and translational glycobiology.

Employment

• Yale University Postdoctoral associate
  2026 - Present

Education

• University of Florida PhD in Chemical Biology
  2021 - 2025

Projects & Funding

Projects & funding information is unavailable.

Publications (12)

• Investigation of Intercellular Trafficking of Global Glycosylphosphatidylinositol-Anchored Proteins Using Cell Metabolic Engineering and Transwell Coculture
  Angewandte Chemie International Edition 2026 DOI: 10.1002/ANIE.202522420
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• Monophosphoryl Lipid A–2,4-Dinitrophenylamine Conjugates Are Potent Adjuvants for Carbohydrate and Protein Vaccines
  JACS Au 2025 DOI: 10.1021/jacsau.5c00187
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• Efficient Enzymatic Glycan Engineering of Extracellular Vesicles Using Nanomaterial-Interfaced Microfluidics
  ACS Applied Materials & Interfaces 2025 DOI: 10.1021/acsami.4c20294
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• Bifunctional glycosphingolipid (GSL) probes to investigate GSL-interacting proteins in cell membranes
  Journal of Lipid Research 2024 DOI: 10.1016/j.jlr.2024.100570
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• Sensitive Method To Analyze Cell Surface GPI-Anchored Proteins Using DNA Hybridization Chain Reaction-Mediated Signal Amplification
  Analytical Chemistry 2024 DOI: 10.1021/acs.analchem.4c01116
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• A Biotinylated Glycosylphosphatidylinositol (GPI) as the Universal Platform To Access GPI-Anchored Protein Analogues
  The Journal of Organic Chemistry 2023 DOI: 10.1021/acs.joc.3c02560
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• Investigation of Glycosylphosphatidylinositol (GPI)‐Plasma Membrane Interaction in Live Cells and the Influence of GPI Glycan Structure on the Interaction
  Chemistry – A European Journal 2023 DOI: 10.1002/chem.202303047
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• Spin-Labeling Insights into How Chemical Fixation Impacts Glycan Organization on Cells
  Applied Magnetic Resonance 2023 DOI: 10.1007/s00723-023-01624-w
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• Different Biophysical Properties of Cell Surface α2,3- and α2,6-Sialoglycans Revealed by Electron Paramagnetic Resonance Spectroscopic Studies
  The Journal of Physical Chemistry B 2023 DOI: 10.1021/acs.jpcb.2c09048
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• Labeling cell surface glycosylphosphatidylinositol-anchored proteins through metabolic engineering using an azide-modified phosphatidylinositol
  Biochemical and Biophysical Research Communications 2023 DOI: 10.1016/j.bbrc.2023.01.029
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