Vadde Ramu
Also known as: Ramu
Ruhr University Bochum, École Normale Supérieure, CSIR National Chemical Laboratory, Leiden University
Research areas: Medicine · Oncology · Metal complexes synthesis and properties · Photodynamic Therapy Research Studies · Nanoplatforms for cancer theranostics
0000-0003-0726-6920
About
Vadde Ramu is a chemical biologist, having completed his Ph.D. in 2016 at the National Chemical Laboratory, India. He is currently working with Prof. Nils-Metzler Nolte’ research group at Ruhr-University Bochum in Germany as Marie-Curie Postdoctoral fellow. He has been working on the various projects on the bioinorganic chemistry since he started his research career in 2010.
After Ph.D. Ramu moved to Germany for first postdoctoral research (1.5 years) to work on two-photo induced carbon monoxide releasing molecules with Prof. Alexander Schiller in University of Jena. Then, he worked at the University of Leiden with Prof. Sylvestre Bonnet in the Netherlands for 2.3 years as postdoctoral researcher in the field of photoactivatable chemotherapeutic molecules where he gained experience on culturing 3D tumor spheroids for testing anti-cancer efficacy of metal complexes in 3 dimensional tumor spheroids under hypoxic conditions. Next, Ramu joined the University of Sorbonne in Paris to work on Re-based small peptide molecule inhibitors for Keap1-Nrf2 protein-protein interactions with Prof. Helene Bertrand. He has worked with Prof. Jim Thomas at the University of Sheffield as exchange researcher student during his Ph.D. in the UKIERI project in 2011.
Recently, Ramu has been awarded Marie Skłodowska-Curie Postdoctoral Fellowships in the year 2021. He was also awarded the National Postdoctoral Fellowship by the Science and Engineering Research Board, India in 2019. Ramu is the recipient of 3 best poster awards by the Royal Society of Chemistry in the international conferences in 2016, authored 2 book chapters and granted a patent to his credit. Ramu has 5 years of postdoctoral research experience in the field of metals in biology and has supervised 5 master students so far. Ramu got an opportunity to present his research work orally at international conferences at CHAINS 2019 Eindhoven, Netherlands and IMBG 2019 Villard de Lans, France and RACPL 2019, Vizag, India.
Employment
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Ruhr University Bochum Marie-Curie Individual Fellow2023 - Present
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Dublin City University Marie-Curie Postdoctoral Fellow2022 - 2024
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École Normale Supérieure Postdoc2021 - Present
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Universiteit Leiden Postdoc2018 - Present
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Friedrich-Schiller-Universität Jena Postdoctoral Fellow2016 - 2018
Education
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CSIR National Chemical Laboratory Doctor of Philosophy2012 - 2016
Projects & Funding
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Image Tumor HORIZON EUROPE Marie Sklodowska-Curie Actions2023 - 2025
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pHOxysense HORIZON EUROPE Marie Sklodowska-Curie Actions2022 - 2024
Publications (24)
- Rational Design of Enzyme-Responsive Fluorescent Organoruthenium Prodrug for Real-Time Tracking of Cargo Release and Cytotoxicity Save
- Oxygen-Dependent Interactions between the Ruthenium Cage and the Photoreleased Inhibitor in NAMPT-Targeted Photoactivated Chemotherapy Save
- Oxygen-dependent interactions between the ruthenium cage and the photoreleased inhibitor in NAMPT-targeted photoactivated chemotherapy Save
- Rhenium fac-Tricarbonyl Bisimine Chalcogenide Complexes: Synthesis, Photophysical Studies, and Confocal and Time-Resolved Cell Microscopy Save
- Cell viability imaging in tumor spheroids via DNA binding of a ruthenium(ii) light-switch complex Save
- Red‐Light Activation of a Microtubule Polymerization Inhibitor via Amide Functionalization of the Ruthenium Photocage Save
- In vivo metallophilic self-assembly of a light-activated anticancer drug Save
- Cytotoxicity of Metal-Based Photoactivated Chemotherapy (PACT)Photoactivated chemotherapy (PACT) Compounds Save
- Carbon Nanomaterials- Based Sensors-Fundamentals of health, safety, and regulation issues of carbon nanomaterial-based sensors Save
- Photosubstitution in a trisheteroleptic ruthenium complex inhibits conjunctival melanoma growth in a zebrafish orthotopic xenograft model Save
- Photoactivable Ruthenium-Based Coordination Polymer Nanoparticles for Light-Induced Chemotherapy Save
- Rollover Cyclometalation vs Nitrogen Coordination in Tetrapyridyl Anticancer Gold(III) Complexes: Effect on Protein Interaction and Toxicity Save
- The self-assembly of a cyclometalated palladium photosensitizer into proteins-stabilized nanorods triggered drug uptake in vitro and in vivo. Save
- TLD1433 photosensitizer inhibits conjunctival melanoma cells in zebrafish ectopic and orthotopic tumour models Save
- Frontispiece: Two‐Photon‐Induced CO‐Releasing Molecules as Molecular Logic Systems in Solution, Polymers, and Cells Save
- Two‐Photon‐Induced CO‐Releasing Molecules as Molecular Logic Systems in Solution, Polymers, and Cells Save
- Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model Save
- A ratiometric sensor for DNA based on a dual emission Ru(dppz) light-switch complex. Save
- Photo-induced cytotoxicity and anti-metastatic activity of ruthenium(ii)-polypyridyl complexes functionalized with tyrosine or tryptophan. Save
- GSH Induced Controlled Release of Levofloxacin from a Purpose-Built Prodrug: Luminescence Response for Probing the Drug Release in Escherichia coli and Staphylococcus aureus. Save