MK

Maheedhar Kodali

Kasturba Medical College, Manipal, Siddhartha Academy of Higher Education

Research areas: Neuroscience · Neurology · Neuroinflammation and Neurodegeneration Mechanisms · Neurological Disease Mechanisms and Treatments · Extracellular vesicles in disease

ORCID iD 0000-0003-0741-4401
Follow

About

Research Interests:
Investigating the molecular and cellular mechanisms of neurodegeneration and identifying therapeutic interventions for Traumatic Brain Injury, Brain Aging, Mild Cognitive Impairment, Alzheimer's Disease, and depression related to Chronic stress

Expertise:
- Development and characterization of preclinical models of Gulf War Illness, Traumatic Brain Injury (TBI), Alzhemier's Disease (AD) Chronic Stress and Temporal Lobe Epilepsy (TLE).
-Extensive experience in survival surgical procedures, including cell transplantation, stereotaxic interventions, and chronic EEG implantation and recording in rodent models.
-Isolation, culture, and characterization of hiPSC astrocytes, and human mesenchymal stem cells (hMSCs), as well as the isolation and functional analysis of extracellular vesicles (EVs).
-Application of advanced single-cell and single-nucleus RNA sequencing (scRNA-seq/snRNA-seq) data analysis to investigate cellular and molecular mechanisms underlying neurological disorders.
-Evaluation of neurological and cognitive outcomes using a comprehensive battery of behavioral and neurocognitive assessments in rodents.
-Investigation of the cellular and molecular pathways regulating neuroinflammation, neurogenesis, neural repair, and neurodegeneration.
-Development of regenerative and cell-based therapeutic strategies aimed at mitigating neurological dysfunction and improving recovery following brain injury and neurodegenerative diseases.

Employment

Employment history is unavailable.

Education

Projects & Funding

Projects & funding information is unavailable.

Publications (2)