Kenta Arai
Tokai University
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Organoselenium and organotellurium chemistry · Redox biology and oxidative stress · Protein Structure and Dynamics
0000-0003-0785-2559
About
Dr. Kenta Arai received his B.Sc. (2008), M.Sc. (2010), and Ph.D. (2012) degrees from Tokai University under supervision of Professor Dr. Michio Iwaoka. In 2013, he moved to United Kingdom as a postdoctoral fellowship of Japan Society for the Promotion Science (JSPS) at School of Chemistry, Cardiff University and studied an electrochemical organic synthesis under supervision of Prof. Dr. Thomas Wirth in 2013-2014. Currently, he is independently progressing his own researches with his students at Tokai University as a junior associate professor. He is a member of the Chemical Society Japan, Protein Science Society of Japan, the Biophysical Society of Japan, American Chemical Society, and Editorial Board of Current Green Chemistry (Bentham Science Publishers).
His research involves synthesis of organoselenium compounds, modelling of ER-redox enzymes, biophysics relevant to a protein folding, electrochemistry, and flow chemistry. He is recently interested in development of drugs for misfolding diseases and anti-oxidative therapy and its application to mammalian cells.
Employment
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Tokai University Junior associate professor2014 - Present
Education
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Tokai University PhD2004 - 2012
Projects & Funding
Projects & funding information is unavailable.
Publications (46)
- From Folding Reagents to Catalysts: Spatially Organized Diselenide−Cyclodextrins Enable Catalytic Oxidative Protein Folding Save
- Beyond Folding Enzymes: A Redox-Active “Solid Chaperone” Unlocks Recyclable, HPLC-Free Oxidative Protein Folding Save
- An Initiator-Free Electrochemical Approach to Radical Thiol–Ene Coupling in a Microfluidic Reactor Save
- Ca2+-triggered allosteric catalysts crosstalk with cellular redox systems through their foldase- and reductase-like activities Save
- ER Oxidoreductin 1‐Like Activity of Cyclic Diselenides Drives Protein Disulfide Isomerase in an Electron Relay System Save
- Boosting the enzymatic activity of CxxC motif-containing PDI family members Save
- Seleno-relaxin analogues: effect of internal and external diselenide bonds on the foldability and a fibrosis-related factor of endometriotic stromal cells Save
- Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity Save
- Modeling Type‐1 Iodothyronine Deiodinase with Peptide‐Based Aliphatic Diselenides: Potential Role of Highly Conserved His and Cys Residues as a General Acid Catalyst Save
- Resin-supported cyclic telluride as a heterogeneous promoter of disulfide formation under solid–liquid biphasic conditions Save
- Semi-enzymatic acceleration of oxidative protein folding by N-methylated heteroaromatic thiols Save
- S-Denitrosylase-Like Activity of Cyclic Diselenides Conjugated with Xaa-His Dipeptide: Role of Proline Spacer as a Key Activity Booster Save
- Abnormal Enhancement of Protein Disulfide Isomerase-like Activity of a Cyclic Diselenide Conjugated with a Basic Amino Acid by Inserting a Glycine Spacer Save
- Glutathione peroxidase-like functions of 1,2-diselenane-4,5-diol and its amphiphilic derivatives: Switchable catalytic cycles depending on peroxide substrates Save
- Flexible folding: Disulfide-containing peptides and proteins choose the pathway depending on the environments Save
- Basic Amino Acid Conjugates of 1,2-Diselenan-4-amine with Protein Disulfide Isomerase-like Functions as a Manipulator of Protein Quality Control Save
- Relaxin-2 may suppress endometriosis by reducing fibrosis, scar formation, and inflammation Save
- Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding Save
- Cyclic telluride reagents with remarkable glutathione peroxidase-like activity for purification-free synthesis of highly pure organodisulfides Save
- Modeling Thioredoxin Reductase-Like Activity with Cyclic Selenenyl Sulfides: Participation of an NH⋅⋅⋅Se Hydrogen Bond through Stabilization of the Mixed Se−S Intermediate Save