Sushila Kumari
NCI at Frederick Scientific Library, Central Drug Research Institute
Research areas: Immunology and Microbiology · Virology · HIV Research and Treatment · HIV/AIDS drug development and treatment · Cellular transport and secretion
About
I was inspired by my parents and teachers in high school to pursue science, specifically biological sciences in my future. I used to talk to the teachers and friends about the wondrous discoveries in life sciences and how these discoveries are making human life better. During my postgraduation in microbiology, I worked in a biochemistry lab at a medical university in India on detection of HIV-1 and malaria, which really inspired me. This amazing experience helped me to develop my research interests in science, especially on microbial involvement in human diseases.
After postgraduation, I qualified Council of Scientific & Industrial Research-Junior Research Fellowship and joined as a Ph.D. student in Dr. Raj Kamal Tripathi's laboratory, CSIR-Central Drug Research Institute, India. During my Ph.D, I addressed long-standing questions on how HIV-1 Nef hijacks the intracellular machinery to promote viral immune evasion and persistence inside the host cells.
During my Ph.D. I gave an oral presentation in a conference in 2018, India where I met Dr. Shilpa Buch, Professor at University of Nebraska Medical Center (UNMC) in Omaha, Nebraska (USA); she gave me an opportunity to join as a student scholar in her laboratory for six months to learn more about HIV-1 research. This was an amazing experience for me, which helped me to understand the molecular basis of Nef-mediated endocytosis of SERINC5, a host restriction factor, in infected cells.
To explore more experiences on the detailed mechanisms of host factors involving in HIV-1 research, I joined in Dr. Pathak’s lab as a Postdoctoral Fellow, one of the leading laboratories working on the understanding of HIV-1 uncoating, nuclear import and the interplay between viral proteins with host restriction factors such as APOBEC3 proteins.
With Science, I am also interested in games specially Table tennis, I made so many memories during PhD.
Employment
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NCI at Frederick Scientific Library Postdoctoral Fellow2020 - Present
Education
- 2015 - 2020
Projects & Funding
Projects & funding information is unavailable.
Publications (5)
- The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores Save
- HIV‐1 Nef hijacks both exocytic and endocytic pathways of host intracellular trafficking through differential regulation of Rab GTPases Save
- HIV-1 Nef-GCC185 interaction regulates assembly of cellular protein complexes at TGN targeting MHC-I downregulation Save
- HIV-1 Nef physically associate with CAMKIIδ – ASK-1 complex to inhibit p38MAPK signalling and apoptosis in infected cells Save
- HIV-1 Nef-POTEE; A novel interaction modulates macrophage dissemination via mTORC2 signaling pathway Save