Shanna Hamilton

Employment

• University of Arizona Assistant Professor
  2023 - Present

Education

Education history is unavailable.

Projects & Funding

• Defining the role of ER stress proteins ERO1alpha and PRDX4 in hereditary calcium-dependent arrhythmia American Heart Association
  2025 - 2028

Publications (23)

• Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy
  The Journal of Physiology 2026 DOI: 10.1113/JP289566
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• Increased Intermembrane Space [Ca 2+ ] Drives Mitochondrial Structural Damage in CPVT
  Circulation Research 2025 DOI: 10.1161/CIRCRESAHA.125.326841
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• The yellow brick road to understanding the RyR2 signalosome
  The Journal of Physiology 2024 DOI: 10.1113/JP287538
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• To block or not to block: Targeting SK channels in diseased hearts.
  Journal of molecular and cellular cardiology 2023 DOI: 10.1016/j.yjmcc.2023.09.005
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• Sexual dimorphism in bidirectional SR-mitochondria crosstalk in ventricular cardiomyocytes.
  Basic research in cardiology 2023 DOI: 10.1007/s00395-023-00988-1
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• ER stress and calcium-dependent arrhythmias.
  Frontiers in physiology 2022 DOI: 10.3389/fphys.2022.1041940
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• CLIC4 localizes to mitochondrial-associated membranes and mediates cardioprotection.
  Devasena Ponnalagu, Shanna Hamilton, Shridhar Kiran Sanghvi +15 more
  Science advances 2022 DOI: 10.1126/sciadv.abo1244
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• Ero1α-Dependent ERp44 Dissociation From RyR2 Contributes to Cardiac Arrhythmia
  Circulation Research 2022 DOI: 10.1161/CIRCRESAHA.121.320531
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• Mitochondrial calpain inhibition restores defective SR-mitochondrial crosstalk in CPVT rat myocytes.
  The Journal of general physiology 2021 DOI: 10.1085/jgp.2021ecc11
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• MCU overexpression evokes disparate dose-dependent effects on mito-ROS and spontaneous Ca2+ release in hypertrophic rat cardiomyocytes.
  American journal of physiology. Heart and circulatory physiology 2021 DOI: 10.1152/ajpheart.00126.2021
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• RyR2 Gain-of-Function and Not So Sudden Cardiac Death.
  Circulation research 2021 DOI: 10.1161/circresaha.121.319651
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• Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia.
  Journal of molecular and cellular cardiology 2021 DOI: 10.1016/j.yjmcc.2021.04.002
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• Interleukin-1β, Oxidative Stress, and Abnormal Calcium Handling Mediate Diabetic Arrhythmic Risk.
  JACC. Basic to translational science 2021 DOI: 10.1016/j.jacbts.2020.11.002
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• The role of calcium homeostasis remodeling in inherited cardiac arrhythmia syndromes.
  Pflugers Archiv : European journal of physiology 2021 DOI: 10.1007/s00424-020-02505-y
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• Impact of ISK Voltage and Ca2+/Mg2+-Dependent Rectification on Cardiac Repolarization.
  Biophysical journal 2020 DOI: 10.1016/j.bpj.2020.06.022
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• Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS.
  Basic research in cardiology 2020 DOI: 10.1007/s00395-020-0797-z
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• Altered Intracellular Calcium Homeostasis and Arrhythmogenesis in the Aged Heart.
  International journal of molecular sciences 2019 DOI: 10.3390/ijms20102386
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• PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts.
  The Journal of physiology 2019 DOI: 10.1113/jp277618
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• Pharmacological Modulation of Mitochondrial Ca2+ Content Regulates Sarcoplasmic Reticulum Ca2+ Release via Oxidation of the Ryanodine Receptor by Mitochondria-Derived Reactive Oxygen Species.
  Frontiers in physiology 2018 DOI: 10.3389/fphys.2018.01831
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• Proarrhythmic Remodeling of Calcium Homeostasis in Cardiac Disease; Implications for Diabetes and Obesity.
  Frontiers in physiology 2018 DOI: 10.3389/fphys.2018.01517
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