Nirmal Saha
Indian Institute of Science Bangalore, Georgia Institute of Technology, University of Kalyani, North Bengal University, Center of Biomedical Research, University of Gour Banga
0000-0003-1114-5187
About
As a highly trained Biochemist, I have dedicated my career to pushing the boundaries of scientific discovery. After earning my PhD in Chemistry, I was awarded consecutive NIH and NSF postdoctoral fellowships at the Georgia Institute of Technology, where I made significant contributions to marine natural product biosynthesis, enzymatic halogenation, and the design of covalent inhibitors of bacterial enzymes.
Now, as a Scientist at the Indian Institute of Science (IISc) Bangalore, I specialize in the intersection of organic synthesis, biocatalysis, enzymology, and drug discovery. My research focuses on Enzyme-activated cancer prodrug discovery and AI-assisted directed evolution, with the goal of developing innovative solutions that can positively impact the lives of those affected by cancer.
I am passionate about leveraging my extensive expertise in biochemistry, enzymology, and natural product synthesis to advance drug discovery. I am particularly skilled in the construction and engineering of biosynthetic pathways using cutting-edge approaches such as Ribosomally Synthesized and Post-Translationally Modified Peptides (RiPPs), brominase, and Sonogashira coupling.
If you are a recruiter seeking highly experienced, skilled scientists or a fellow scientist, researcher, or industry professional interested in collaborating on groundbreaking projects at the forefront of biochemistry and drug discovery, I welcome the opportunity to connect. Let's explore how we can work together to unlock new possibilities and make a meaningful impact on the world.
Employment
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Indian Institute of Science Bangalore Postdoctoral Scientist2026 - 2027
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Georgia Institute of Technology Postdoc2022 - 2026
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Center of Biomedical Research2016 - 2022
Education
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University of Kalyani PhD2017 - 2021
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North Bengal University Master of Science2013 - 2015
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University of Gour Banga Bachelor of Science2010 - 2013
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Lalit Mohan Shyam Mohini High School (H.S) Higher Secondary2008 - 2010
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Maheshpur High School (H.S) Secondary Education (10 th)2003 - 2008
Projects & Funding
Projects & funding information is unavailable.
Publications (12)
- Halogenase-Assisted Biocatalytic Derivatization of Aminothiazoles and Cephalosporin Antibiotics Save
- Transformation-Guided Genome Mining Provides Access to Brominated Lanthipeptides Save
- Halogenase-Assisted Alkyne/Aryl Bromide Sonogashira Coupling for Ribosomally Synthesized Peptides Save
- Highly Efficient One-Pot Multienzyme Cascades for the Stereoselective Synthesis of Natural Naphthalenones Save
- Concise chemoenzymatic total synthesis of (−)-rubroskyrin, (−)-deoxyrubroskyrin (−)-luteoskyrin, and (−)-deoxyluteoskyrin Save
- Chemoenzymatic total synthesis of nodulones C and D using a naphthol reductase of Magnaporthe grisea Save
- Asymmetric Synthesis of Nodulones C & D by Chemoenzymatic Approach gives Insight into their Biosynthesis Save
- A Biomimetic Synthesis of Racemic Dihydroanthracen-1(2H )-ones Using Sodium Borohydride in Water Save
- Asymmetric Synthesis of Natural cis-Dihydroarenediols Using Tetrahydroxynaphthalene Reductase and Its Biosynthetic Implications Save
- Chemoenzymatic reduction of citreorosein and its implications on aloe-emodin and rugulosin C (bio)synthesis Save