Emmanuel Mfotie Njoya
Université de Yaoundé I Faculté des Sciences
Research areas: Agricultural and Biological Sciences · Plant Science · Medicinal Plant Research · Phytochemical Studies and Bioactivities · Phytochemistry and Biological Activities
About
I obtained a Ph.D. in Biochemistry at the University of Yaoundé I (Cameroon) graded as excellent. I specialised in natural product pharmacology and toxicology, precisely developing drugs from natural substances targeting oxidative stress, inflammation, infectious diseases, and cancer. As a research scientist with several international awards in biochemistry, I have consistently demonstrated my commitment to academic excellence and a global perspective on scientific research. I have been awarded the Calmette and Yersin Research Grant from the International Pasteur Network at the Cell Biology of Parasitism Unit of the Pasteur Institute of Paris (France), where my research was centred on unveiling the molecular mechanisms of plant-isolated substances against Entamoeba histolytica, the parasite responsible for intestinal amoebiasis. Next, through a one-year DAAD (German Exchange Service) fellowship at the Institute of Pharmacology and Toxicology, University of Würzburg (Germany), I have evaluated the safety of bioactive substances on several cellular and animal models. The results from this work have led to the formulation of an efficient and safe improved traditional medicine (Covarium™10) developed to treat patients suffering from intestinal amoebiasis. This achievement reflects my commitment to ethical research practices and sustainable development in advancing drug discovery from nature.
Furthermore, I have earned several postdoctoral awards at the University of Pretoria, the Central University of Technology (South Africa), and the Chengdu Institute of Biology (China), and I have also received the Alexander von Humboldt Award (Georg Forster Fellowship) at the Martin Luther University of Halle-Wittenberg (Germany). The experiences gained from these trainings have shaped my approach to both basic and applied sciences, allowing me to foster international collaborations and thus contributing meaningfully to global research initiatives. With 10+ years of research experience and project management, I have successfully led pre-clinical R&D projects, aiming to advance the discovery of innovative therapies against infectious diseases, oxidative stress and inflammatory-related diseases such as Alzheimer’s disease and cancer. I have strong experience in mammalian cell culture and cell-based assays, as well as designing, developing, and validating biochemical assays for testing the efficacy and safety of drug substances; the study of signalling pathways using molecular biology techniques; and the isolation of natural compounds using phytochemical techniques such as HPLC and LC-MS. To date, I have co-supervised a Ph.D., an M.Sc. and a Pharm. diploma, and I have authored 40+ peer-reviewed publications and delivered 5+ national and international oral presentations to diverse audiences. Additionally, I have also served as an instructor, where I participated in teaching practical courses and tutorials in pharmacology, drug metabolism, in vitro toxicological methods, structural biochemistry, cell biology, and biochemical techniques to undergraduate and master’s students. The combination of the above-mentioned technical skills, my international experience, and my collaborative mindset makes me a great fit for several jobs related to biomedical sciences.
Employment
Employment history is unavailable.
Education
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Université de Yaoundé I Faculté des Sciences PhD (Pharmacology)2010 - 2015
Projects & Funding
Projects & funding information is unavailable.
Publications (48)
- Anti-Inflammatory and Cough-Modulating Effects of Plantago lanceolata and Sisymbrium officinale in Upper Airway Infections: A Narrative Review Save
- Comparative Effects of Flurbiprofen and Benzydamine on COX-2/PGE2 and Inflammatory Cytokine Release in Polyinosinic:polycytidylic Acid-Stimulated Human Tonsil and Bronchial Epithelial Cells Save
- Evaluation of Plantago lanceolata (Ribwort Plantain) and StrepCough Plantain-Dry Cough Syrup in In Vitro Models of Pharyngitis and Cough Save
- Cytotoxicity and structural manipulations of biomimetic salicylidene based compounds Save
- Unveiling the antioxidant and anti-inflammatory potentials of Gomphostigma virgatum and analyzing its phytochemical profile Save
- Therapeutic Potential of Natural Xanthones Against Prostate Adenocarcinoma: A Comprehensive Review of Research Trends During the Last Ten Years (2014–2024) Save
- Buxus natalensis (Oliv.) Hutch (Buxaceae) Exhibits Its Anticancer Potential by Stimulating ROS Production and Caspase-p53-BCL-2-Dependent Apoptosis in Hepatocellular Carcinoma and Prostate Cancer Cell Lines Save
- New cerebrosides and ceramide with other constituents from the aerial parts of Raphidiocystis mannii Hook. f. and their cytotoxic activities Save
- The Antioxidant and Anti-Inflammatory Activities of the Methanolic Extract, Fractions, and Isolated Compounds from Eriosema montanum Baker f. (Fabaceae) Save
- Anti-elastase, Anti-tyrosinase, and Anti-inflammatory Activities of Three Compounds Isolated from Psorospermum aurantiacum: In Silico and In Vitro Assays Save
- Bioactive Fractions Isolated from Harungana madagascariensis Lam. and Psorospermum aurantiacum Engl. Regulate Collagen and Melanin Biosynthesis Gene Expression in UVB-Irradiated Cells with Additional Anti-Inflammatory Potential Save
- Epicatechin Isolated from Litchi chinensis Sonn. (Litchi) Fruit Peel Ethyl Acetate Extract Modulated Glucose Uptake in Chang Cells and Suppressed ROS Production in RAW 264.7 Macrophages Save
- Insight into the molecular mechanism of anti-breast cancer therapeutic potential of substituted salicylidene-based compounds using cell-based assays and molecular docking studies Save
- Investigating the Phytochemical Composition, Antioxidant, and Anti-Inflammatory Potentials of Cassinopsis ilicifolia (Hochst.) Kuntze Extract against Some Oxidative Stress and Inflammation Molecular Markers Save
- Phytoconstituents of Androstachys johnsonii Prain Prevent Reactive Oxygen Species Production and Regulate the Expression of Inflammatory Mediators in LPS-Stimulated RAW 264.7 Macrophages Save
- Unravelling the Influence of Chlorogenic Acid on the Antioxidant Phytochemistry of Avocado (Persea americana Mill.) Fruit Peel Save
- Anti-elastase, anti-tyrosinase and anti-inflammatory activities of three compounds isolated from Psorospernum aurantiacum Engl.: in- silico and in- vitro assays Save
- Asperpyrone, a rare α-pyrone metabolite produced by an endophytic fungus Aspergillus sp. isolated from Garicinia smeathmannii (Planch. & Triana) Oliv. Save
- In Vitro Filaricidal Properties of Hydro-Methanolic Extracts of Powdery Fractions of Khaya senegalensis (Meliaceae) on Onchocerca ochengi Save
- In vitro antiproliferative, anti-inflammatory effects and molecular docking studies of natural compounds isolated from Sarcocephalus pobeguinii (Hua ex Pobég) Save