Calliope Dendrou
Kennedy Institute of Rheumatology, Reuben College, University of Oxford, University of Cambridge, Imperial College London, Centre for Human Genetics
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Single-cell and spatial transcriptomics · Genetic Associations and Epidemiology · T-cell and B-cell Immunology
0000-0003-1179-4021
About
Calliope Dendrou is an Associate Professor in Clinical Pathology and Inflammation at the Kennedy Institute of Rheumatology (KIR) where she leads the Immune Disease Multiomics Laboratory. She previously held a Wellcome & Royal Society Sir Henry Dale Fellowship to start her group in 2017 at the Centre for Human Genetics in Oxford, where she was also the Equality, Diversity and Inclusion Champion, before moving to the KIR in 2023. Calli’s research focuses on investigating shared molecular circuits and cellular mechanisms across tissues and across immune-mediated diseases. Her group uses high-resolution genomic profiling technologies to help elucidate cross-disease pathophysiology, particularly as pathological drivers may evolve over time and may change due to environmental influences and therapeutic intervention. Her research aims to identify ‘hubs’ that may be targeted therapeutically via drug repositioning approaches, with an especial emphasis on cytokine signalling pathways. She is also the Data Analysis Lead for several large-scale collaborative projects including the Oxford-J&J Cartography Consortium and the Chan Zuckerberg Initiative LEGACY Network, and enjoys teaching on the MSc in Genomic Medicine programme, as the ‘Single-Cell & Spatial Omics for Precision Medicine’ Module Lead.
Employment
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Kennedy Institute of Rheumatology Associate Professor in Clinical Pathology and Inflammation2024 - Present
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Reuben College, University of Oxford Official Fellow in Cellular Life2023 - Present
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Kennedy Institute of Rheumatology KTRR Group Leader in Clinical Pathology2023 - Present
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Wellcome Trust Centre for Human Genetics Principal Investigator (Sir Henry Dale Fellow)2017 - 2023
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Balliol College, University of Oxford Research Fellow in the Sciences (Medical)2017 - 2020
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University of Oxford Senior Postdoctoral Researcher2013 - 2017
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University of Oxford Postdoctoral Researcher2010 - 2013
Education
- 2005 - 2009
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Imperial College London BSc in Biology2002 - 2005
Projects & Funding
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Stop the clock on chronic inflammation Wellcome Trust Ltd2026 - 2034
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Establishing biomarkers to predict patient drug response in inflammatory bowel disease Medical and Life Sciences Translational Fund2025 - 2026
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Fibrosis Unmasked: A Metabolic Cell Odyssey Across Tissues and Diseases Novo Nordisk (Denmark)2025 - 2028
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SAGITTARIUS AbbVie (United States)2025 - 2030
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Oxford-GSK Alliance Experimental Medicine Centre GlaxoSmithKline (United Kingdom)2025 - 2030
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Lymph nodE single cell Genomics AnCestrY immunity, infection, inflammation and immunisation (LEGACY IIII) Network Medical Research Council2025 - 2029
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MRC CoRE in Exposome Immunology Medical Research Council2025 - 2032
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Cartography 3.0 Johnson & Johnson (United States)2024 - 2027
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Identification of antigens targeted by T-cells mediating GvL & GvHD following Stem Cell Transplant CRUK2024 - 2029
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Phase 1a, Multi Centre Vaccine Trial of VAC096 and Associated Immunology Bill and Melinda Gates Foundation2023 - 2027
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The case for a Childhood Therapeutic Atlas Chan Zuckerberg Initiative (United States)2023 - 2026
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Lymph Node Single-Cell Genomics Ancestry (LEGACY) Network Chan Zuckerberg Initiative (United States)2022 - 2026
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Tissue research in childhood inflammatory arthritis (TRICIA consortium) Medical Research Council2022 - 2027
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Cartography 2.0 Janssen Inc.2022 - 2024
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Precision genome editing with tandem autologous transplantation as a therapy for multiple severe immune-mediated diseases Medical Research Council2021 - 2023
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Cartography 1.0 Janssen Inc.2021 - 2023
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Mapping human inflammatory response kinetics in ethnically diverse groups Chan Zuckerberg Initiative (United States)2019 - 2023
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An Extended Pilot for the Human Cell Atlas: Adult tissues, human development and inflammation-mediated pathologies Wellcome2018 - 2022
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Therapeutically mimicking SNPs Nimbus Therapeutics2018 - 2022
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Tyrosine kinase 2: A genetically determined drug target for multiple autoimmune diseases Rosetrees Trust2018 - 2022
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Human Immune Discovery Initiative Genomics platform NIHR Oxford Biomedical Research Centre2018 - 2020
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Investigating the functional basis of shared genetic etiology across autoimmune diseases Wellcome Trust Ltd2017 - 2024
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Studying the effects of pregnancy in MS Aims2Cure2016 - 2019
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Translating Big Data Into New Treatments Frances and Augustus Newman Foundation2015 - 2018
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Functional immunogenetics of neurodegeneration Takeda Pharmaceutical Company2015 - 2018
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The International Neuromyelitis Optica Genetics Consortium Guthy-Jackson Charitable Foundation2015 - 2017
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A genetically-determined drug target for MS Rosetrees Trust2014 - 2017
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MS genetics: informing clinical practice Rosetrees Trust2012 - 2014
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CD25, a type 1 diabetes gene encoding the alpha chain of the interleukin-2 receptor: cellular phenotypes assocaited with susceptibility and resistance genotypes. Wellcome Trust2005 - 2009
Publications (69)
- Epigenetic modulation of stromal cell states underpins pathological tissue niches in Crohn's disease. Save
- Identification of genetic risk loci associated with aquaporin 4-positive neuromyelitis optica spectrum disorder: a genome-wide association study. Save
- Protocol for precision cutting and short-term culture of lymph node tissue slices for modeling of innate immune responses ex vivo. Save
- Single-cell and spatial transcriptomic analyses of gene therapy-associated retinal inflammation in non-human primates. Save
- Experiences of participant engagement from an African and Asian ancestry cohort during a clinical research study of lymph node responses to influenza immunisation in the United Kingdom Save
- Early lymph node T follicular helper cell signalling hub drives influenza vaccine response in an ancestrally diverse cohort. Save
- Navigating the Hepatic Immune Landscape With Fine Needle Aspiration of the Liver-An Emerging Technique. Save
- Insights, opportunities, and challenges provided by large cell atlases. Save
- Synovial matrix turnover controls immune cell spatial patterning in inflammation resolution. Save
- Single-cell and spatial transcriptomic analyses of gene therapy-associated retinal inflammation in non-human primates Save
- Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity Save
- Ex vivo model of functioning human lymph node reveals role for innate lymphocytes and stroma in response to vaccine adjuvant. Save
- Regulatory T cells attenuate chronic inflammation and cardiac fibrosis in hypertrophic cardiomyopathy. Save
- Single-cell eQTL mapping identifies disease-specific genetic control of COVID-19 infection Save
- CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue. Save
- Immune-epithelial-stromal networks define the cellular ecosystem of the small intestine in celiac disease. Save
- Investigating endogenous immune-mediated monocyte memory in rheumatoid arthritis. Save
- Early regional lymph node activation drives influenza vaccine responses in an ancestrally diverse cohort Save
- A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease. Save
- CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue Save