NV
Niek van Hilten
University of California, San Francisco, Leiden University, Radboud University Nijmegen
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Lipid Membrane Structure and Behavior · Protein Structure and Dynamics · Computational Drug Discovery Methods
0000-0003-1204-2489
Employment
- 2023 - Present
-
Leiden University PhD Candidate2018 - 2023
Education
- 2018 - 2023
- 2015 - 2017
- 2013 - 2015
- 2010 - 2013
Projects & Funding
-
The role of TMEM16F in phosphatidylserine exposure as a blood clotting signal American Heart Association2026 - 2028
Publications (20)
- CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly Save
- Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties Save
- A conserved salt bridge network stabilizes the hepatic organic anion transporters OATP1B1 and OATP1B3 Save
- A cell-based scrambling assay reveals the phospholipid headgroup preference of TMEM16F on the plasma membrane Save
- Physics-based evolution of transmembrane helices reveals mechanisms of cholesterol attraction Save
- Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove Save
- Atypical cofilin signaling drives dendritic cell migration through the extracellular matrix via nuclear deformation Save
- When Data Are Lacking: Physics-Based Inverse Design of Biopolymers Interacting with Complex, Fluid Phases Save
- PMIpred: a physics-informed web server for quantitative protein–membrane interaction prediction Save
- Phase‐Separated Lipid‐Based Nanoparticles: Selective Behavior At The Nano‐Bio Interface Save
- Inverse design of curvature-sensing antiviral peptides Save
- Physics-based generative model of curvature sensing peptides; distinguishing sensors from binders Save
- Azobenzene-based amino acids for the photocontrol of coiled-coil peptides Save
- Efficient Quantification of Lipid Packing Defect Sensing by Amphipathic Peptides: Comparing Martini 2 and 3 with CHARMM36 Save
- Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor. Save
- Membrane Thinning Induces Sorting of Lipids and the Amphipathic Lipid Packing Sensor (ALPS) Protein Motif Save
- Virtual Compound Libraries in Computer-Assisted Drug Discovery. Save
- Binding-Site Compatible Fragment Growing Applied to the Design of β2-Adrenergic Receptor Ligands. Save
- Potent metabolic sialylation inhibitors based on C-5 modified fluorinated sialic acids Save
- Steering Siglec-Sialic Acid Interactions on Living Cells using Bioorthogonal Chemistry. Save