Samrat Mukhopadhyay
Indian Institute of Science Education and Research (IISER) Mohali, Scripps Research Institute, Indian Institute of Science
0000-0003-1242-9958
About
Samrat Mukhopadhyay obtained his Ph.D. in organic chemistry from the Indian Institute of Science, Bangalore in 2004. Following a short stint as a Visiting Fellow at the Tata Institute of Fundamental Research (TIFR) Mumbai, he moved to the United States for his postdoctoral work at the Scripps Research Institute in California. During his postdoctoral stint at Scripps, he also worked with (late) Prof. Susan Lindquist at Whitehead Institute, MIT, in a collaboration to study a yeast prion using single-molecule techniques. He returned to India in December 2008 and joined as an Assistant Professor (now promoted to Professor) at a newly set up institution, Indian Institute of Science Education and Research (IISER) Mohali. He holds a joint appointment at the Department of Biological Sciences and the Department of Chemical Sciences at IISER Mohali. His lab is involved in elucidating molecular details of the key events in both pathological and functional amyloids derived from intrinsically disordered proteins (IDPs). The intrinsic disorder in the proteins allows the complex organisms to carry out multiple functions by the same proteins by adopting different conformational states. However, the disorder-to-function relationship is poorly understood. Additionally, dysfunction of many IDPs is associated with a range of deadly diseases such as Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis (ALS), frontotemporal dementias (FTDs) and cancers. The Mukhopadhyay lab utilizes a diverse range of approaches involving biophysics, biochemistry, chemical biology, cell and molecular biology, and advanced single-molecule and ultrafast spectroscopy to gain molecular insights into the conformational ensemble and dynamics, the protein hydration water, liquid-liquid phase separation, aggregation and amyloid formation from various IDPs containing low-complexity and prion-like domains. These studies are beginning to illuminate the unique molecular insights into the pivotal functional and pathological aspects of phase transition of IDPs.
Employment
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Indian Institute of Science Education and Research (IISER) Mohali Professor2020 - Present
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Indian Institute of Science Education and Research (IISER) Mohali Associate Professor2013 - 2020
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Indian Institute of Science Education and Research (IISER) Mohali Assistant Professor2008 - 2013
Education
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Scripps Research Institute Postdoc2005 - 2008
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Indian Institute of Science PhD (Integrated MS & PhD)1997 - 2004
Projects & Funding
Projects & funding information is unavailable.
Publications (93)
- An autoinhibitory regulatory switch governs heterotypic phase separation and liquid-to-solid phase transition of TDP-43 and tau into cytotoxic amyloids Save
- Sequence‐encoded determinants drive distinct early aggregation pathways and different structural outcomes in PNT1 fibrils across Henipavirus members Save
- Chaperone-mediated heterotypic phase separation regulates liquid-to-solid phase transitions of tau into amyloid fibrils Save
- The regulation of virulence gene expression is controlled by phase separation of heterochromatin protein 1 (HP1) in Plasmodium falciparum Save
- Unraveling the molecular grammar and the structural transitions underlying the fibrillation of a viral fibrillogenic domain Save
- Intermolecular energy migration via homoFRET captures the modulation in the material property of phase-separated biomolecular condensates Save
- Distance-Dependent Tryptophan-Induced Quenching of Thioflavin T Defines the Amyloid Core Architecture Save
- Chaperone-mediated heterotypic phase separation prevents the amyloid formation of the pathological Y145Stop variant of the prion protein Save
- Hydrogen-Bonded Network of Water in Phase-Separated Biomolecular Condensates Save
- Chaperone-mediated heterotypic phase separation regulates liquid-to-solid phase transitions into amyloid fibrils Save