Neelaveni Thangavel
RVS College of Pharmaceutical Sciences, Jazan University, Jadavpur University
0000-0003-1282-2311
About
Research Interests:
My research interests encompass the development of novel antidiabetic agents, particularly through synthesizing selective PPAR-γ modulators. I employ molecular docking and dynamics simulations to investigate compound-receptor interactions, enhancing our understanding of drug mechanisms. Additionally, I specialize in pharmaceutical analysis, focusing on developing and validating analytical methods using HPLC and GC-MS to identify and quantitatively estimate pharmaceutical formulations. I also explore the pharmacological potential of natural products in cancer therapy, aiming to advance drug discovery and improve therapeutic strategies in diabetes and cancer treatment.
Key Areas of Expertise
• Leveraging In-Silico Techniques for Drug Discovery: Enhancing the success rate of drug design through molecular and pharmacophore modeling, molecular dynamics simulations, and virtual screening using tools such as AutoDock, AutoDock Vina, Chimera, Discovery Studio, Pyrex, PharmaGist, LigandScout, SwissADME, Osiris, PyMol, Open Babel, Desmond, and GroMacs.
• Computational and Experimental Exploration of Natural Resources: Identifying potential therapeutic agents for diabetes, cancer, and viral infections through high-throughput computational screening, followed by chromatographic isolation and structural characterization using IR, NMR, and Mass spectroscopy.
• Preclinical Evaluation of Drug Candidates: Conducting in-vitro and in-vivo studies to assess the efficacy and safety of anti-diabetic and anti-cancer herbal formulations, synthetic leads, and their analogues.
• Sustainable Organic Synthesis for Drug Discovery: Utilizing non-conventional energy sources to promote atom economy and minimize environmental impact in the synthesis of potential drug candidates.
• Analytical Method Development and Validation: Designing and validating UV spectroscopy, HPLC, and GC-MS methods for the quantitative estimation of pharmaceutical compounds in marketed formulations and biological matrices.
• Statistical Validation and Data Analysis: Applying statistical tools such as GraphPad Prism and SPSS for result validation and data interpretation.
• Research Funding and Grant Applications: Drafting compelling research proposals and grant applications to secure funding for innovative pharmaceutical research.
Employment
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RVS College of Pharmaceutical Sciences Professor and Principal2024 - Present
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Jazan University Professor2012 - 2024
Education
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Jadavpur University PhD2001 - 2007
Projects & Funding
Projects & funding information is unavailable.
Publications (32)
- Formulation and evaluation of curcumin-loaded superporous hydrogels Save
- Benchmarking docking, density functional theory and molecular dynamics studies to assess the aldose reductase inhibitory potential of Trigonella foenum-graecum compounds for managing diabetes-associated complications Save
- A comprehensive overview of selective and novel fibroblast growth factor receptor inhibitors as a potential anticancer modality Save
- Synthesis, molecular docking, and in vivo antidiabetic evaluation of new benzylidene-2,4-thiazolidinediones as partial PPAR-γ agonists Save
- Therapeutic implications of current Janus kinase inhibitors as anti-COVID agents: A review Save
- Structural Complementarity of Bruton’s Tyrosine Kinase and Its Inhibitors for Implication in B-Cell Malignancies and Autoimmune Diseases Save
- Benchmarked molecular docking integrated molecular dynamics stability analysis for prediction of SARS-CoV-2 papain-like protease inhibition by olive secoiridoids Save
- Pharmacophore model-aided virtual screening combined with comparative molecular docking and molecular dynamics for identification of marine natural products as SARS-CoV-2 papain-like protease inhibitors Save
- Formulation, biopharmaceutical evaluation and in-vitro screening of polyherbal phytosomes for breast cancer therapy Save
- Strategies to Improvise Organ Donor Pool: A Study on the Knowledge, Attitudes, and Performance of Higher Secondary School Teachers Towards the Organ Donation Save