0000-0003-1299-0091 About
Dr. Rajendra Joshi holds a Masters degree in Biochemistry from the University of Pune and a Doctorate in Biochemistry from National Chemical Laboratory (University of Pune). He has also served as a faculty member at the Bioinformatics Centre, University of Pune. Prior to his doctorate he also has industrial experience where he has worked on the development of vaccines. He has been associated with the area of Biotechnology & Bioinformatics more than 33 years. He has over 28 years of experience in the area of Bioinformatics, which includes experience as a faculty member at the Bioinformatics Centre, University of Pune. He is primarily responsible for building a strong bioinformatics group at C-DAC and served as a Senior Director and Head of the Department of the High Performance Computing: Medical and Bioinformatics Applications Group (HPC-M&BA), at C-DAC. He is also the convener of the Expert Group on Applications Development of the National Supercomputing Mission of the Government of India. He is presently serving as a Senior Consultant at the HPC-M&BA group at C-DAC.
At C-DAC he has been instrumental in setting up the Bioinformatics Resources and Applications Facility (BRAF), which serves as a nodal point for all researchers in life sciences who require high speed computing. The BRAF facility has served a platform for setting up collaborations in India and across the globe. This facility has been the key to the Indo-US collaboration with the NCI (NIH), USA. Similarly, he has responsible to setup the Indo-UK collaboration with the Biotechnology and Biological Sciences Research Council (BBSRC, UK). He has been leading a number of large projects of national importance.
His major area of expertise, is in the use of high performance parallel computers for biological research. His unique strength is in the form of good knowledge of biology and parallel computing. His main research interests include, molecular dynamics simulations of nucleic acids & proteins, genome sequence analysis, metabolic pathways and development of software environments. He is a principal investigator for funded projects and other research projects, leading to a number of publications in international journals and conferences. He is actively involved in collaborative programmes and national scientific meets. He has numerous publications, articles and invited talks to his credit. His career objective is to build an environment where much of biology could be understood using high performance parallel computers.
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Publications (100)
- Unlocking the potential of RNAi as a therapeutic strategy against infectious viruses: an in-silico study Save
- A Study Modeling Bridged Nucleic Acid-Based ASOs and Their Impact on the Structure and Stability of ASO/RNA Duplexes Save
- Studying early structural changes in SOS1 mediated KRAS activation mechanism Save
- MolToxPred: small molecule toxicity prediction using machine learning approach Save
- Multi-ensemble machine learning framework for omics data integration: A case study using breast cancer samples Save
- Design of LNA Analogues Using a Combined Density Functional Theory and Molecular Dynamics Approach for RNA Therapeutics Save
- Probing the structure of human tRNA3Lys in the presence of ligands using docking, MD simulations and MSM analysis Save
- Markov State Modeling Analysis Captures Changes in the Temperature-Sensitive N-Terminal and β-Turn Regions of the p53 DNA-Binding Domain Save
- MC1R diversity and its role in skin pigmentation variation in West Maharashtra, India Save
- A Deep Dive into the Conformational Dynamics of CYP3A4 : Understanding the Binding of Homotropic and Non-homotropic Ligands for Mitigating Drug-Drug interaction (DDI) Save