Dapeng Zhou
Tongji University, MD Anderson Cancer Center, Princeton University, University of Zurich, Shanghai Medical College of Fudan University
0000-0003-1347-3811
About
Zhou laboratory focuses on immunologic function of glycoconjugates, and published glycolipid and glycopeptide epitopes involved in cancer. These studies have led to licensing of cancer-specific monoclonal antibodies to BioLegend USA, and STEMCELL Technologies, Canada. Zhou and colleagues' discoveries have been cited in textbooks of glycobiology and immunology, including Handbook of Glycosyltransferases and Related Genes (for cloning of iGb3 synthase, Lc3 synthase and b-3 glycosyltransferase gene family), Essentials of Glycobiology (for discovering glycolipid antigen iGb3 and its metabolic pathways), and Fundamental Immunology (for discovering the role of saposins in assisting loading of glycolipid antigens to CD1). Zhou has received the Cancer Research Institute Irvington Postdoctoral Fellowship Award, People's Republic of China Ministry of Education's Chunhui Prize for Innovation and Entrepreneurship, and PRC's 1000Plan Professorship for Young Talents.
Dr. Zhou received his M.D. and M.Sc. degree from Shanghai Medical College (Fudan University), before a PhD degree in the glycobiology laboratory of Eric Berger at University of Zurich, Switzerland. He did postdoctoral research in the laboratory of Albert Bendelac at Princeton University and University of Chicago (HHMI). He started independent research at the University of Texas M.D. Anderson Cancer Center, and was promoted to Associate Professor. He was recruited back to China by the national 1000Plan Project for young talents. Currently he is leading a glycoimmunology group in Tongji University. Dr. Zhou is committee member of Glycobiology section under Chinese Society of Biochemistry and Molecular Biology, and committee member of Virology section under Shanghai Medical Association. He has been author of more than 60 publications including Nature, Science, Journal of Clinical Investigation, Journal of Proteome Research, Journal of Biological Chemistry, Glycobiology, and Carbohydrate Research.
Employment
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Tongji University2015 - Present
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MD Anderson Cancer Center2006 - 2014
Education
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Princeton University Postdoctoral fellow2002 - 2002
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University of Zurich1997 - 2002
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Shanghai Medical College of Fudan University1989 - 1997
Projects & Funding
Projects & funding information is unavailable.
Publications (78)
- A humanized 16A antibody conjugated with DNA topoisomerase I inhibitors, targeting a GSTA glycosite-signature epitope Save
- DMBT1 promotes SARS-CoV-2 infection and its SRCR-derived peptide inhibits SARS-CoV-2 infection Save
- IgG1-Dominant Antibody Response Induced by Recombinant Trimeric SARS-CoV-2 Spike Protein with PIKA Adjuvant Save
- Structural basis of a high-affinity antibody binding to glycoprotein region with consecutive glycosylation sites Save
- Potent Neutralization Antibodies Induced by a Recombinant Trimeric Spike Protein Vaccine Candidate Containing PIKA Adjuvant for COVID-19 Save
- An antibody‐drug conjugate targeting a GSTA glycosite‐signature epitope of MUC1 expressed by non‐small cell lung cancer Save
- Identification of 22 N-glycosites on spike glycoprotein of SARS-CoV-2 and accessible surface glycopeptide motifs: Implications for vaccination and antibody therapeutics Save
- Separation and detection of minimal length glycopeptide neoantigen epitopes centering the GSTA region of MUC1 by liquid chromatography/mass spectrometry Save
- Induction of antitumor immunity in mice by the combination of nanoparticle-based photothermolysis and anti-PD-1 checkpoint inhibition Save
- Immunogenicity of Del19 EGFR mutations in Chinese patients affected by lung adenocarcinoma Save