KB
Katherine S. Bridge
University of York, Barts Cancer Institute Centre for Molecular Oncology, University of Nottingham
Research areas: Biochemistry, Genetics and Molecular Biology · Cancer Research · Cancer, Hypoxia, and Metabolism · Gene expression and cancer classification · Molecular Biology Techniques and Applications
0000-0003-1516-1459
Employment
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University of York Lecturer2024 - Present
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University of York Kay Kendall Intermediate Fellow2021 - Present
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University of York Centre for Future Health Fellow2019 - 2021
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Barts Cancer Institute Centre for Molecular Oncology BBSRC Research Co-investigator2015 - 2018
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Barts Cancer Institute Centre for Molecular Oncology Postdoctoral Research Assistant2012 - 2014
Education
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University of Nottingham PhD in Molecular Cell Biology2009 - 2013
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University of Nottingham BSc (Hons) in Biochemistry2006 - 2009
Projects & Funding
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Dissecting the role of pathologically co-opted HIF-1 within aberrant RNA-splicing driving malignant haematopoiesis Medical Research Council2025 - 2028
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Targeting sodium signalling to combat the disease-driving effects of tumour hypoxia Medical Research Council2023 - 2026
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Application of the miniatuRIME method to analyse glucocorticoid receptor transcription complexes in primary healthy and leukaemic T-cells Biotechnology and Biological Sciences Research Council2023 - 2025
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Reprogramming HIF in hematopoiesis: deciphering the code to hack a master regulator Kay Kendall Leukaemia Fund2021 - 2024
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Characterisation of a new mechanism of regulation for HIF1 and the hypoxic response. Biotechnology and Biological Sciences Research Council2014 - 2018
Publications (27)
- Aberrant splicing of MBD1 reshapes the epigenome to drive convergent myeloerythroid defects in MDS Save
- JAK2V617F reprograms Hypoxia Inducible Factor-1 to induce a non-canonical hypoxia regulon in myeloproliferative neoplasms Save
- LungCHEM-Py: a computational model to predict asthma exacerbation risk from indoor air pollutants Save
- Building a transparent and functional laboratory culture: guidelines for creating a Laboratory Handbook for principal investigators Save
- An ERα-Dependent Hypoxia Response Defines EMT-Adjacent Tumour Regions and Suppresses the Pro-survival Effects of Amiloride in Estrogen Receptor-Positive Breast Cancer Save
- Identification of robust RT-qPCR reference genes for studying changes in gene expression in response to hypoxia in breast cancer cell lines Save
- Identification of robust RT-qPCR reference genes for studying changes in gene expression in response to hypoxia in breast cancer cell lines Save
- HIF-1 activated by PIM1 assembles a pathological transcription complex and regulon that drives JAK2V617F MPN disease Save
- Hypoxia-induced epigenetic regulation of breast cancer progression and the tumour microenvironment Save
- PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia Save
- ZMIZ1 enhances ERα-dependent expression of E2F2 in breast cancer Save
- The CKS1/CKS2 Proteostasis Axis Is Crucial to Maintain Hematopoietic Stem Cell Function Save
- Physioxia improves the selectivity of hematopoietic stem cell expansion cultures Save
- Aberrant Splicing of MBD1 Reshapes the Epigenome to Drive Convergent Myeloerythroid Defects in MDS Save
- In Breast Cancer ZMIZ1 Co-Regulates E2F2 as Part of the Estrogen Receptor-Mediated Cell-Cycle Response Save
- UNRAVELLING THE EFFECTS OF THE JAK2 V617F MUTATION ON HIF-1 FUNCTION AT THE CHROMATIN Save
- Markers for human haematopoietic stem cells: The disconnect between an identification marker and its function Save
- Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes Save
- Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures Save
- Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes Save