Mehar Sahu

About

Mehar is a dedicated researcher in the field of molecular biology, specializing in the study of LRRK2 and its role in Parkinson’s disease. Currently a Postdoctoral Researcher at the University of Dundee in the MRC Protein Phosphorylation & Ubiquitylation Unit (PPU), Mehar is contributing to the LITE Project, focusing on kinase signaling, protein phosphorylation, and ubiquitination to develop new therapeutic strategies for neurodegenerative diseases.

Previously, Mehar's research centered on BRCA1, an E3 ligase crucial for DNA repair, and its potential role in modulating the accumulation of tau protein in Alzheimer's disease. Through rigorous experimentation and interdisciplinary collaboration, Mehar aims to uncover novel therapeutic avenues for neurodegenerative disorders, including Parkinson’s disease and Alzheimer’s.

By exploring the molecular mechanisms underlying these diseases and the roles of key proteins involved, Mehar aspires to contribute to the development of targeted interventions to improve patient outcomes and restore cognitive function.

Employment

• MRC Protein Phosphorylation and Ubiquitylation Unit Postdoctoral Researcher
  2025 - Present
• Delhi Technological University Project Intern
  2021 - 2021
• DRDO Institute of Nuclear Medicine and Allied Sciences Intern
  2019 - 2019
• DRDO Institute of Nuclear Medicine and Allied Sciences Summer Intern
  2018 - 2018
• Amity University Amity Institute of Biotechnology Trainee
  2017 - 2017
• Amity University Amity Institute of Biotechnology Summer Intern
  2016 - 2016

Education

• Delhi Technological University Master of Technology
  2019 - 2021
• Amity University Bachelors in Biotechnology
  2015 - 2019

Projects & Funding

Projects & funding information is unavailable.

Publications (12)

• IoT-driven augmented reality and virtual reality systems in neurological sciences
  Internet of Things 2024 DOI: 10.1016/j.iot.2024.101098
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• Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases
  Ageing Research Reviews 2024 DOI: 10.1016/j.arr.2023.102174
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• Simulation and Computational Study of RING Domain Mutants of BRCA1 and Ube2k in AD/PD Pathophysiology
  Molecular Biotechnology 2024 DOI: 10.1007/s12033-023-01006-4
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• E3 ligase activity of RNF168 at stake on ring domain mutation
  Journal of the Neurological Sciences 2023 DOI: 10.1016/j.jns.2023.121447
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• RING Domain Mutation Hinders the E3 Ligase Activity of RNF8 and Affects UBE2N Binding
  2023 International Conference on Network, Multimedia and Information Technology (NMITCON) 2023 DOI: 10.1109/nmitcon58196.2023.10276155
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• Cross talk mechanism of disturbed sleep patterns in neurological and psychological disorders
  Neuroscience & Biobehavioral Reviews 2022 DOI: 10.1016/j.neubiorev.2022.104767
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• Free radical biology in neurological manifestations: mechanisms to therapeutics interventions
  Environmental Science and Pollution Research 2022 DOI: 10.1007/s11356-021-16693-2
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• Protein S-sulfhydration: Unraveling the prospective of hydrogen sulfide in the brain, vasculature and neurological manifestations
  Ageing Research Reviews 2022 DOI: 10.1016/j.arr.2022.101579
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• Artificial intelligence and machine learning in precision medicine: A paradigm shift in big data analysis
  Progress in Molecular Biology and Translational Science 2022 DOI: 10.1016/bs.pmbts.2022.03.002
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• Artificial intelligence to deep learning: machine intelligence approach for drug discovery.
  Molecular diversity 2021 DOI: 10.1007/s11030-021-10217-3
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