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OLIVIER COLOMBAN

Université Claude Bernard Lyon 1, Mapi-Naxis (MAPI GROUP), Aix-Marseille Université

ORCID iD 0000-0003-1671-3470
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About

Cancer researcher with over 15 years of experience applying advanced mathematics and statistical modeling in oncology within the EA 3738 CICLY team (Centre for Innovation in Cancer of Lyon) at Lyon-Sud Medical School, Université Claude Bernard Lyon 1 (UCBL).

With dual Master’s degrees in Engineering Mathematics (DESS, 2005) and Biostatistics (DEA, 2006) from UCBL, I joined the team in 2008. My work integrates cutting-edge mathematical frameworks and computational techniques to solve complex biomedical challenges. I specialize in pharmacokinetic-pharmacodynamic (PK/PD) modeling, non-linear mixed effect models, and regression analyses, leveraging these tools to drive innovation in biomarker kinetics and oncology research.

Over the last decade, my primary focus has been on developing and refining mathematical models to describe the kinetics of serum tumor markers (CA-125, PSA, hCG, HE4, nucleosomes), enabling more precise biomarker analysis. Explore this work further at: https://www.biomarker-kinetics.org.

Currently, I lead the development of the KELIM methodology and manage IT operations for the research unit, ensuring seamless integration of computational tools with scientific inquiry.

Key Expertise:
- Advanced mathematical modeling in biomedical contexts;
- Statistical analysis and computational mathematics;
- Non-Linear Mixed Effect Modeling;
- Pharmacokinetics-Pharmacodynamics modeling & simulation;
- Biomarker kinetics and predictive modeling (CA-125, PSA, hCG, etc.);
- Regression models (linear, survival, logistic, etc.);
- Software proficiency: NONMEM, R, MONOLIX, SAS (stat/macro);
- IT management and infrastructure optimization;
- Operating systems: Windows, Windows Server 2019/2008, Mac.

Employment

  • Université Claude Bernard Lyon 1 Quantitative Modeling Engineer | Research
    2008 - Present
  • Mapi-Naxis (MAPI GROUP) Statisticien
    2007 - 2008
  • Université Claude Bernard Lyon 1 Chargé d'étude
    2006 - 2007

Education

  • Université Claude Bernard Lyon 1 DEA Modélisation en Épidémiologie & Recherche Clinique
    2005 - 2006
  • Université Claude Bernard Lyon 1 DESS Statistique, Informatique et Techniques Numériques
    2004 - 2005
  • Aix-Marseille Université 4 years university degrees in applied mathematics to economics
    2000 - 2004

Projects & Funding

Projects & funding information is unavailable.

Publications (54)