Sai Manohar Thota

About

Experienced cancer researcher specializing in metabolomics, with expertise in liquid chromatography and mass spectrometry. Successfully conducted postdoctoral research for 3 years, focusing on health disparities and creating a unique metabolic biomarker panel for early detection of prostate cancer in the African American community. PhD involved designing and executing clinical experiments with patients and disease model systems. Possess 7 years of research experience in Huntington's disease, including experiment design and collaboration with diagnostic centers, hospitals, research institutes, and patients in India. Skilled in molecular docking studies of lead compounds for neurological disorders and establishing a yeast model system lab for in-vitro and in-vivo experiments at the Institute.

Employment

• Baylor College of Medicine  Postdoctoral Research Associate
  2022 - Present
• Sri Sathya Sai Institute of Higher Medical Sciences Whitefields Clinical Observer and Research Coordinator
  2017 - 2019

Education

• Sri Sathya Sai Institute of Higher Learning M.Sc. Biosciences (Biotechnology)
  2011 - 2013

Projects & Funding

Projects & funding information is unavailable.

Publications (11)

• Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation.
  Disease models & mechanisms 2022 DOI: 10.1242/dmm.049492
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• Multimodal Imaging and Visual Evoked Potentials Reveal Key Structural and Functional Features That Distinguish Symptomatic from Pre-symptomatic Huntington’s Disease Brain
  Neurology India 2021
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• Design, stereoselective synthesis, computational studies and cholinesterase inhibitory activity of novel spiropyrrolidinoquinoxaline tethered indole hybrid heterocycle
  Journal of Molecular Structure 2021 DOI: 10.1016/j.molstruc.2020.129165
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• Cholinesterase inhibitory activity of highly functionalized fluorinated spiropyrrolidine heterocyclic hybrids
  Saudi Journal of Biological Sciences 2021 DOI: 10.1016/j.sjbs.2020.11.005
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• Screening for novel lead compounds targeting benzodiazepine allosteric binding site of wild-type and H129Y variant of GABAA receptor: an in-silico molecular docking study
  International Journal of Computational Biology and Drug Design 2021
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• Natural products as home-based prophylactic and symptom management agents in the setting of COVID-19.
  Phytotherapy research : PTR 2020 DOI: 10.1002/ptr.6794
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• Design, synthesis and cholinesterase inhibitory activity of novel spiropyrrolidine tethered imidazole heterocyclic hybrids
  Bioorganic & Medicinal Chemistry Letters 2020 DOI: 10.1016/j.bmcl.2019.126789
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• Highly functionalized 2-amino-4H-pyrans as potent cholinesterase inhibitors
  Bioorganic Chemistry 2018 DOI: 10.1016/j.bioorg.2018.08.009
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• Spiropyrrolidine/spiroindolizino[6,7-b]indole heterocyclic hybrids: Stereoselective synthesis, cholinesterase inhibitory activity and their molecular docking study
  Bioorganic Chemistry 2018 DOI: 10.1016/j.bioorg.2018.04.025
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• Ionic liquid-enabled synthesis, cholinesterase inhibitory activity, and molecular docking study of highly functionalized tetrasubstituted pyrrolidines
  Bioorganic Chemistry 2018 DOI: 10.1016/j.bioorg.2018.01.019
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