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Dr. Souvik Dey

Manipal Academy of Higher Education, Jadavpur University, Kent State University

ORCID iD 0000-0003-1799-5270
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About

My current research interest lies in the area of reproductive biomedicine and on better understanding of the biochemistry of the gamete functions in mammalian systems and exploration of its translational aspects for treatment of infertility issues in human.

Another area of my research interest is on the study of the biotherapeutics with special emphasis on its use in pathophysiological profiling and regulation of cell signaling mechanisms involved in human diseases including cancer and male infertility.

During my post-doctoral research tenure I worked on the biochemistry of mammalian sperm function, specifically delineation of the interrelation between GSK3 and Calcineurin in the regulation of sperm motility and fertility. Earlier I worked on the elucidation of signal transduction mechanism regulating sperm Glycogen synthase kinase 3 (GSK3) activities under influence of the cAMP-PKA axis. It also included the identification of substrates of Protein kinase A and GSK3 using Chemical-genetics and Proteomics approach.

During my doctoral research work, I was involved in the purification, characterization and deciphering signal transduction mechanism of a glycoprotein from mammalian blood serum.


Details in reverse chronological order:


Assistant Professor - Research (November, 2021 – present):

Working as a DBT-Ramalingaswami Fellow (Assistant Professor grade) on molecular and biochemical aspects of male infertility in the Manipal Center for Biotherapeutics Research, Manipal Academy of Higher Education (MAHE), Manipal, KA, India.

Setting up of independent facilities for my ‘Molecular Signal Transduction Group’.

Exploring the interrelation between glycogen synthase kinase 3 (GSK3) and FTO in the regulation of mammalian spermatogenesis and fertility.

Development of reversible male contraceptives targeting PP2B and GSK3α.

Determination of isoform-specific substrates of GSK3 in mammalian sperm.

Targeting of GSK3 isoforms selectively to mitigate cancer phenotypes.


DBT-Faculty (August, 2020 – October, 2021):

Worked as an Assistant Professor (DBT-Ramalingaswami Fellow) on molecular and biochemical aspects of male infertility in the Department of Pharmaceutical Technology, Jadavpur University, Kolkata, WB, India.

Setting up of independent facilities for my ‘Sperm Biology Lab’.

Teaching: Biology classes for B. Pharm. Students: Pathophysiology, Remedial Biology.


Post doctoral (December, 2015 – June, 2020):

Worked as a Post-doctoral Research Associate on Reproductive physiology in the Department of Biological Sciences, Kent State University, Ohio, USA.

Delineating the interrelation between GSK3 and Calcineurin in regulation of mammalian sperm motility and fertility. Based on my preliminary work we got one RO3 grant in 2018 entitled “Regulation of sperm metabolism and fertility by calcineurin and GSK3” (ref: R03HD096176-01).

Elucidation of signal transduction mechanism regulating mammalian sperm GSK3 activity under influence of cAMP-PKA axis.

Investigation of binding partners of a sperm phosphokinase, viz. GSK3 using chemical-genetics based proteomics approach and conventional biochemical ways like pull-down and co-immunoprecipitation techniques using wild type and knock-out mice.

Identification of the isoform-specific functions of GSK3α enzyme in relation to fertilization potential of mouse spermatozoa.

Development of reversible male contraceptives targeting PP2B (International patent Application No.: PCT/US20/36899; Confirmation No.: 9132).


Additional responsibilities:

Guiding and planning of research work for undergraduate and graduate students in the lab.


Awards & Honours:

1. Awarded Ramalingaswami Re-entry Fellowship in 2020 by Department of Biotechnology (DBT), India.

2. Received NIH Travel Awards for attending 43rd and 44th Annual Conference of American Society of Andrology as an oral presenter in Portland, Oregon, USA held on April 21-24, 2018 and in Chicago, Il held on April 6-9, 2019, respectively.

3. Awarded Senior Research Fellowship (SRF) by Indian Council of Medical Research (ICMR) in 2014.

4. Received Junior Research Fellowship (JRF) on Project by DBT, India in 2010.

5. CSIR-UGC NET (LS) in 2010 (all India rank-48) and 2008 by Council for Scientific & Industrial Research-University Grant Commission, India.

6. Awarded Institutional Junior Research Fellowship (JRF) by Chittaranjan National Cancer Institute, Kolkata in 2009.

7. Qualified GATE-Life Sciences in 2008 & 2009 conducted by Human Resource Development Group, GOI.

8. Awarded National Scholarship for performance in Madhyamik (10th standards) by Govt. of West Bengal, India.

Employment

  • Manipal Academy of Higher Education Senior Assistant Professor
    2025 - Present
  • Manipal Academy of Higher Education DBT-Ramalingaswami Fellow & Assistant Professor
    2021 - 2025
  • Jadavpur University DBT-Ramalingswami Fellow & Assistant Professor
    2020 - 2021
  • Kent State University Postdoctoral Research Associate
    2015 - 2020

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (35)