Alexandra G. Fraga
Also known as: Alexandra Fraga
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal; ICVS/3B’s - PT Government Associate Laboratory, University of Minho
Research areas: Medicine · Infectious Diseases · Tuberculosis Research and Epidemiology · Mycobacterium research and diagnosis · Leprosy Research and Treatment
0000-0003-2029-1629
About
Alexandra G. Fraga holds a degree in Applied Biology, a PhD in Health Sciences and is currently a junior researcher at the Microbiology and Infection Research Domain at the Life and Health Sciences Research Institute (ICVS), University of Minho.
Alexandra Fraga’s main areas of specialization include:
- Immunology of infection: study of the host immune responses against infections by pathogenic mycobacteria, specifically Mycobacterium ulcerans and Mycobacterium tuberculosis.
- Prevention and treatment strategies: modulation of the host immune response as well as the bacterial activity by using new vaccine strategies and systems of antimicrobial drug delivery.
- Human genetics: identification of the regulatory effects of interindividual genetic variation on molecular and cellular processes of mycobacterial immunity that will aid in the design of novel prognostic, diagnostic and therapeutic targets for a personalized medical approach for mycobacterial diseases.
- Animal experimentation: experience in the mouse and guinea pig model of infection under BSL2 and BSL3 conditions. FELASA Category C accreditation for animal experimentation by the Portuguese National Authority for Animal Health (DGAV).
- Biosafety and biosecurity: implementation and dissemination of institutional and personal preventive measures to promote the safe handling of biological agents and reduce the risk of individual exposure and avoid the risk of intentional removal or misuse of a biological agent with the intention of causing harm.
Employment
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Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal; ICVS/3B’s - PT Government Associate Laboratory
Education
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School of Health Sciences, University of Minho PhD in Health Sciences2006 - 2010
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University of Minho Applied Biology1999 - 2003
Projects & Funding
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ICVS/3B's - Associate Laboratory Fundação para a Ciência e a Tecnologia2024 - 2024
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Immunometabolic requirements in Buruli Ulcer Fundação para a Ciência e a Tecnologia2023 - 2024
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In vitro screening-based selection and in vivo efficacy evaluation of bacteriophages as potential new assets in the topical treatment of Buruli Ulcer disease. GlaxoSmithKline España2023 - 2026
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ICVS/3B's - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos Fundação para a Ciência e a Tecnologia2021 - 2025
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A flexible platform for generating synthetic virus to control infectious diseases Caixa d'Estalvis i Pensions de Barcelona2021 - 2024
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Extracellular Vesicles as Potential Biomarkers in Fabry Disease Progression Amicus Therapeutics SLU2021 - 2024
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Reinforcing the response to COVID-19 pandemic by improving diagnostic tools and capacity (ReCOVMi) Fundação para a Ciência e a Tecnologia2020 - 2022
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Viral-Based Bioconjugation Platform (ViBBiP) for vaccines development against bacterial pathogens European Society of Clinical Microbiology and Infectious Diseases2020 - 2021
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ICVS/3B's - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group Fundação para a Ciência e a Tecnologia2019 - 2019
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lmmunogenetic determinants of susceptibility/resistance to Buruli ulcer: a family- and population-based study for a neglected tropical disease Fundação para a Ciência e a Tecnologia2018 - 2021
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Development of a novel colour-coded RING FISH method: an innovative tool for the detection of antibiotic resistant clinical pathogens Fundação para a Ciência e a Tecnologia2016 - 2019
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SynPhage: Construction of synthetic phages to combat infectious bacterial diseases Fundação para a Ciência e a Tecnologia2016 - 2019
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Transcriptome Analysis of Animal Models of Spontaneous Healing of Buruli Ulcer European Commission2016 - 2019
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Strategic Project - LA 26 - 2013-2014 Fundação para a Ciência e a Tecnologia2013 - 2014
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Buruli ulcer - from understanding the mechanisms of host resistance to the development of new interventions against emerging mycobacterioses Fundação Calouste Gulbenkian2009 - 2012
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Impacto em saúde pública de micobacterioses de difícil tratamento: tuberculose multi-resistente e úlcera do Buruli Calouste Gulbenkian Foundation2002 - 2005
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Role of Interleukin-23 (IL-23) and IL-17 in the regulation of the immune response to the infection by Mycobacterium tuberculosis Science and Technology Foundation, Ministry of Education and Science
Publications (45)
- The orphan receptor GPR84 drives inflammation in Buruli ulcer development Save
- The orphan receptor GPR84 drives inflammation in Buruli ulcer development. Save
- Antimicrobial properties of hindered amine light stabilizers in polymer coating materials and their mechanism of action Save
- Inflammation and Exosomes in Fabry Disease Pathogenesis Save
- Discovery of 2,9-diaryl-6-carbamoylpurines as a novel class of antitubercular agents Save
- Repurposing of statins for Buruli Ulcer treatment: antimicrobial activity against Mycobacterium ulcerans Save
- Development of polyurethane antimicrobial coatings by composition with phenolic-, ionic- and copper-based agents Save
- Gellan gum spongy-like hydrogel-based dual antibiotic therapy for infected diabetic wounds Save
- The impact of single-cell genomics on the field of mycobacterial infection Save
- An optimized mouse model of Staphylococcus aureus infected diabetic ulcers Save
- Development of an antibiotics delivery system for topical treatment of the neglected tropical disease Buruli ulcer Save
- Multiple facets and functions of the toxin mycolactone produced by Mycobacterium ulcerans Save
- Purification and Characterization of a Thrombolytic Enzyme Produced by a New Strain ofBacillus subtil Save
- Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer Save
- Genetics in the Host-Mycobacterium ulceransm ulcerans interaction Save
- Individual and clinical variables associated with the risk of Buruli ulcer acquisition: A systematic review and meta-analysis. Save
- The Immunology of Buruli Ulcer Save
- Increasing the potential of cell-penetrating peptides for cancer therapy using a new pentagonal scaffold Save
- Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ulcerans infection. Save
- K2 Capsule Depolymerase Is Highly Stable, Is Refractory to Resistance, and Protects Larvae and Mice from Acinetobacter baumannii Sepsis Save