Paul Gray
Sydney Children's Hospital Randwick, Camden and Campbelltown Hospitals, UNSW Sydney, University of Edinburgh, Sydney Children's Hospital, University of Cambridge Gonville and Caius College
Research areas: Immunology and Microbiology · Immunology · Immunodeficiency and Autoimmune Disorders · T-cell and B-cell Immunology · Blood disorders and treatments
0000-0003-2057-3968
About
Doctor Paul Gray a clinical paediatric allergist, immunologist and immunopathologist, specialising in childhood immunodeficiency, allergy and inflammatory disease. His interest in immunology began during his undergraduate degree at Cambridge where he undertook Honours in immunology and virology, and was jointly awarded the University prize in Immunology.
Dr Gray completed training in paediatric immunology and immunopathology between the U.K. and Australia. He specialised in clinical immunology and immunopathology and is Joint Head of Immunology and Infectious Diseases at Sydney Children’s Hospital, Randwick.
He has twelve years of consultant level experience, managing patients with Primary Immunodeficiency and inflammatory disease. His PhD is in the genetics of inborn errors of immunity, and he has gathered a cohort of more than 100 patients with rare genetic disorders of the immune system for genomic studies.
He is a founding member of the Clinical Immunogenetics Research Consortium of Australia (CIRCA) and is deeply involved in genomic diagnosis and novel gene discovery, working with patient selection as well as data filtering and variant curation. He has more than 60 peer-reviewed publications, mostly in
the field of inborn errors of immunity, and has a range of international collaborations, which have resulted in the discovery of a number of immunogenetic syndromes.
Employment
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Sydney Children's Hospital Randwick Joint Head of Department2016 - Present
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Campbelltown Hospital Staff Specialist in Paediatric Immunology and Allergy2011 - Present
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Sydney Children’s Hospital Staff Specialist – Paediatric Immunology & Allergy2011 - Present
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Great Ormond Street Hospital Registrar2009 - 2010
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Sydney Children’s Hospital Registrar2008 - 2010
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Sutherland Hospital Immunopathology Registrar2006 - 2008
Education
- 2011 - Present
- 1997 - 2000
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University of Cambridge Gonville and Caius College B.A. Hons1994 - 1997
Projects & Funding
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De novo mutations and the pathogenesis of childhood-onset autoimmune disease National Health and Medical Research Council2016 - 2021
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Clinical Immunogenomics Research Consortium Australia (CIRCA) Office of Health and Medical Research of the New South Wales Government2015 - Present
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Clinical Immunogenomics Research Consortium Australia (CIRCA) Sydney Children's Hospital Network - Costco2015 - 2016
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Use of next generation sequencing to identify the gene underlying familial orbital myositis Royal Australasian College of Physicians2012 - 2012
Publications (90)
- Disease associations for rare immune genetic variants require statistical or rule-based support Save
- Not getting the nod: The case against Yao syndrome Save
- Inborn Errors of Immunity and Autoimmune Disease Save
- Infliximab Reverses Symptoms and May Protect from Developing Chronic Restrictive Ophthalmopathy in Children with Familial Orbital Myositis: A Case Report Save
- Dendritiform immune cells with reduced antigen-capture capacity persist in the cornea during the asymptomatic phase of allergic conjunctivitis. Save
- Increased dendritic cell density and altered morphology in allergic conjunctivitis. Save
- A cell-based functional assay that accurately links genotype to phenotype in Familial HLH Save
- Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination. Save
- A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes Save
- The FOXP3 full-length isoform controls the lineage-stability of CD4+FOXP3+ regulatory T cells Save
- COVID ‐19 in children: I. Epidemiology, prevention and indirect impacts Save
- COVID ‐19 in children: Pathogenesis, disease spectrum and management Save
- Hyper-IgE Syndrome due to an Elusive Novel Intronic Homozygous Variant in DOCK8 Save
- Severe COVID‐19 represents an undiagnosed primary immunodeficiency in a high proportion of infected individuals Save
- Intrinsic Defects in B Cell Development and Differentiation, T Cell Exhaustion and Altered Unconventional T Cell Generation Characterize Human Adenosine Deaminase Type 2 Deficiency Save
- 'The expansion of human T-bethighCD21low B cells is T cell dependent Save
- SAMD9L autoinflammatory or ataxia pancytopenia disease mutations activate cell-autonomous translational repression Save
- Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency Save
- The Role of ZEB2 in Human CD8 T Lymphocytes: Clinical and Cellular Immune Profiling in Mowat–Wilson Syndrome Save
- Somatic reversion of pathogenic DOCK8 variants alters lymphocyte differentiation and function to effectively cure DOCK8 deficiency Save