Nilimesh Das

About

B.Sc. from Scottish Church College and M.Sc. from Presidency University as the gold medalist.

My PhD is from IIT Kanpur, where I worked on the protein behaviour in the crowded environment by applying a single molecular technique: FCS, and some ultrafast spectroscopic techniques like TCSPC and transient absorption spectroscopy. I also involved in a few projects about the photophysics of nanomaterials, the mystery of solvent mixture, fluorescence sensing of important metal ions and molecular level structure of deep eutectic solvents.

Currently, I am doing a postdoc in Harvard Medical School, where I am studying the mechanistic role of RNA binding proteins on its effect on central dogma using methods like single molecular FRET and optical tweezer.

Employment

• Harvard University Research Associate
  2023 - Present
• IIT Kanpur Postdoc
  2023 - 2023

Education

• Presidency University M.Sc
  2013 - 2015
• Scottish Church College B.Sc
  2009 - 2013

Projects & Funding

Projects & funding information is unavailable.

Publications (40)

• Dissecting the role of substrate folding in enzymatic digestion
  Biointerphases 2025 DOI: 10.1116/6.0004803
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• Transient Poly(ADP-Ribose) Triggers FUS Condensation Hysteresis via a Prion-Like Mechanism
  2025 DOI: 10.1101/2025.07.03.659157
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• Critical Role of Water beyond the Media to Maintain Protein Stability and Activity in Hydrated Deep Eutectic Solvent
  The Journal of Physical Chemistry B 2025 DOI: 10.1021/acs.jpcb.4c07039
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• FUS nanoclusters are a distinct state within the dilute phase
  Nature Communications 2025 DOI: 10.1038/s41467-025-64909-7
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• Macromolecular crowding effects on protein dynamics
  International Journal of Biological Macromolecules 2024 DOI: 10.1016/j.ijbiomac.2024.136248
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• Role of Associated Water Dynamics on Protein Stability and Activity in Crowded Milieu
  The Journal of Physical Chemistry B 2024 DOI: 10.1021/acs.jpcb.4c04337
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• Tracking heterogenous protein aggregation at nanoscale through fluorescence correlation spectroscopy
  Photochemistry and Photobiology 2024 DOI: 10.1111/php.14004
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• The shift of excitation spectra at blue edge of emission (BEEmS) as a new methodology to probe heterogeneity
  Chemical Physics 2024 DOI: 10.1016/j.chemphys.2023.112138
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• DDX6 Regulates the Assembly, Size and Fluidity of FUS Condensates
  Ssrn 2024 DOI: 10.2139/ssrn.5055158
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• Understanding the intricacy of protein in hydrated deep eutectic solvent: Solvation dynamics, conformational fluctuation dynamics, and stability
  International Journal of Biological Macromolecules 2023 DOI: 10.1016/j.ijbiomac.2023.127100
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