Sharmistha Banerjee
University of Hyderabad School of Life Sciences, Centre for DNA Fingerprinting and Diagnostics
0000-0003-2263-7320
About
Sharmistha Banerjee received her Ph.D. in Biochemistry in 2005 from University of Hyderabad. She worked at Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India, and later continued her postdoctoral studies at the Laboratory of Transcriptional Biology on mechanisms of Rho-dependent termination in E.coli. She worked briefly at Molecular Cardiology Unit, Lerner Research Institute, The Cleveland Clinic, Cleveland, USA on role of integrins in prostate cancer metastasis.
Presently, as a Professor in the Department of Biochemistry, School of Life Sciences, she teaches Immunology and Enzymology along with various topics on Infectious diseases and host pathogen interactions.
Research Interests
The Research focus of her laboratory is molecular pathogenesis and immunology of Mycobacterium tuberculosis(M.tb), Human Immunodeficiency Virus (HIV) and M.tb-HIV co-infection.
The laboratory is working on two human pathogens, Mycobacterium tuberculosis [tuberculosis (TB) causing bacteria] and Human Immunodeficiency Virus (HIV), the synergistic pandemic of which is a major health concern in India and worldwide. The laboratory, in the last few years, has added important baseline information on molecular mechanisms behind pathogenesis of HIV and mycobacteria, during both mono-and co-infection, identifying potential drug targets and biomarkers. Presently, the following themes are under investigation:
(a) Cellular and Molecular Mechanisms of Mycobacterial physiology: Deciphering adaptive metabolic and regulatory networks of Mycobacterium tuberculosis in response to infection and related stresses through proteomics and metabolomics; identification and validation of critical enzymes as potential targets and screening small molecule inhibitors against these targets for anti-mycobacterial activity.
(b) Molecular insights into HIV Biology: Investigating perturbations in nuclear architecture during HIV-1 infection and studying the molecular basis of differential regulation of viral persistence and propagation in diverse cell types.
(c) Molecular Mechanismsof M.tb-HIV co-infection: System-wide studies to identify the concurrent perturbations in the proteomes of both host cell and intracellular mycobacteria during HIV co-infection and deciphering the underlying molecular mechanisms.
Honours and Awards:
• Chancellor’s Award 2017, University of Hyderabad
• National Women Bioscientist Award (Young Category) 2016, from Department of Biotechnology, Govt. of India
• Prof BK Bachhawat International Travel Grant for Young Scientists 2018
• Innovative Young Biotechnologist Award (IYBA) 2011, from the Department of Biotechnology, Govt. of India
• BioAsia Innovation Award 2008
• INSA Young Scientist Award 2005, from the Indian National Science Academy.
Employment
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University of Hyderabad School of Life Sciences Professor2006 - Present
Education
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Centre for DNA Fingerprinting and Diagnostics PhD2000 - 2005
Projects & Funding
Projects & funding information is unavailable.
Publications (64)
- C-Terminal Domain of Mycobacterium tuberculosis Glutamate Decarboxylase determines the bacterial stress-adaptive metabolic state that steers macrophage polarisation supporting intracellular persistence Save
- Cefpiramide Restricts Mycobacterium tuberculosis Growth by Binding to the DNA-Binding Domain of an Essential Response Regulator, MtrA Save
- Riluzole Enhances Latency Reversal Agent Efficacy in ART-Suppressed PWH by Relieving hnRNPA1-Mediated HIV-RNA Nuclear Export Block Save
- Virion Associated Importin Subunit Beta‐1 Augments Nuclear Import of HIV‐1 Pre‐Integration Complex Save
- Bird’s Eye View on Mycobacterium tuberculosis–HIV Coinfection: Understanding the Molecular Synergism, Challenges, and New Approaches to Therapeutics Save
- Rv0547c, a functional oxidoreductase, supports Mycobacterium tuberculosis persistence by reprogramming host mitochondrial fatty acid metabolism Save
- Confronting Tuberculosis: A Synthetic Quinoline-Isonicotinic Acid Hydrazide Hybrid Compound as a Potent Lead Molecule Against Mycobacterium tuberculosis Save
- The stage-specific regulation imposed by Importinβ-1 on HIV-1 propagation and infectivity dynamics Save
- The nuclear pore protein NUP98 impedes LTR-driven basal gene expression of HIV-1, viral propagation, and infectivity Save
- HIV-1 Tat commandeers nuclear export of Rev-viral RNA complex by controlling hnRNPA2-mediated splicing Save