MD

Mandar V. Deshmukh

Centre for Cellular and Molecular Biology CSIR, Centre for Cellular and Molecular Biology, University of California San Francisco, Technische Universität München Fachgebiet Technikgeschichte

ORCID iD 0000-0003-2447-9725
Follow

About

Dr. Deshmukh is one of the leading structural biologists who primarily utilizes solution NMR techniques to study the non-coding RNA mediated gene regulation pathway. He has established the solution NMR driven structural biology group at CSIR – CCMB. He is primarily studying RNA binding proteins that play an important role in gene regulation. His work extend our understanding of Dicers:dsRBPs:dsRNA ternary complex formation which is crucial for functioning of RNAi pathway in various organisms ranging from C. elegans to A. thaliana. Results obtained from his lab elaborate on the structural divergence in seemingly conserved and highly homologous proteins that imply a fine balance and further suggest that a subtle change can make or break the RNA mediated gene silencing. The results exemplify that the process of RNAi initiation is unique for each organism and is heavily dependent on step-wise assembly of the Dicer, its partner proteins, and the trigger small RNA. Additionally, his lab probes structure-function relationships in regulatory RNAs such as riboswitches and RNA binding proteins in prokaryotes. The solution structure of Crc (32kDa) -presumably the largest solution structure from the country- showed that the Crc has divergently evolved from APendonucleases and adopted a novel RNA binding face. His strengths lie in utilizing multi-faceted approach involving structural biology, NMR driven dynamics, biophysics, biochemistry and molecular biology to understand the organization of the complex protein:nucleic acids assemblies. His work is well recognized in the field as evident from invited talks in many national and international meetings and publications in highly acclaimed journals.

Dr. Mandar V. Deshmukh obtained an M.Sc. degree in Chemistry from Dr. B. A. M. University, Aurangabad and learnt NMR techniques applied to study polymer blends and LCST polymers at the National Chemical Laboratory, Pune with Dr. S. Ganapathy and Dr. M. G. Kulkarni. For his doctoral research, Dr. Deshmukh worked in Prof. Horst Kessler's lab at Technical University of Munich. He used high-end solution NMR methods to study inter-domain dynamics in multi-domain proteins. Later, he moved to the University of California, San Francisco to train with Prof. John D. Gross as a postdoctoral fellow. During his postdoc, he investigated structural aspects of Dcp2, a key decapping enzyme that acts on mature mRNA.

Employment

  • Centre for Cellular and Molecular Biology CSIR Senior Principal Scientist
    2020 - Present
  • Centre for Cellular and Molecular Biology CSIR Principal Scientist
    2015 - 2020
  • Centre for Cellular and Molecular Biology CSIR Sr. Scientist
    2010 - 2015
  • Centre for Cellular and Molecular Biology Scientist
    2006 - 2010

Education

  • University of California San Francisco Postdoctoral Scholar
    2004 - 2006
  • Technische Universität München Fachgebiet Technikgeschichte Ph.D.
    2000 - 2004

Projects & Funding

Projects & funding information is unavailable.

Publications (32)