Umesh Chopra
Indian Institute of Science Bangalore, Jawaharlal Nehru University, University of Delhi
0000-0003-2731-0810
About
🔬 Microbiologist | Host-Pathogen Interactions | Immunology | Intracellular Pathogen Biology
I hold a Ph.D. in Microbiology and Cell Biology from the Indian Institute of Science (IISc), Bangalore, where I explored the intricate mechanisms employed by Salmonella to evade immune responses and manipulate host cellular pathways. My research focused on how Salmonella effectors remodel the endoplasmic reticulum (ER), activate the unfolded protein response (UPR), and facilitate Salmonella-containing vacuole (SCV) division. Additionally, I investigated how this pathogen upregulates programmed death ligand-1 (PD-L1) expression to suppress T cell activation, revealing a critical immune evasion strategy.
My research interests include host–microbe interactions, mucosal immunity, intracellular organelle dynamics, and pathogen-driven immunomodulation.
Employment
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Indian Institute of Science Bangalore Research Associate2024 - Present
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Indian Institute of Science Bangalore Senior Research Fellow (PhD)2021 - 2024
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Indian Institute of Science Bangalore Junior Research Fellow (PhD)2019 - 2021
Education
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Indian Institute of Science Bangalore PhD2019 - 2025
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Jawaharlal Nehru University MSc2017 - 2019
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University of Delhi BSc2014 - 2017
Projects & Funding
Projects & funding information is unavailable.
Publications (4)
- Unravelling Salmonella Pathogenesis: Effector-Mediated Post-Translational Modifications, Alternative Therapies, and Advances in Rapid Detection Save
- Endoplasmic reticulum facilitates the coordinated division of Salmonella -containing vacuoles Save
- Salmonellaeffector SseL induces PD-L1 up-regulation and T cell inactivation via β-catenin signalling axis Save
- TLR-mediated aggresome-like induced structures comprise antimicrobial peptides and attenuate intracellular bacterial survival. Save