Panicos Shangaris
King's College London, North Middlesex University Hospital, Royal Free London NHS Foundation Trust
Research areas: Biochemistry, Genetics and Molecular Biology · Cell Biology · Mesenchymal stem cell research · Hematopoietic Stem Cell Transplantation · Pluripotent Stem Cells Research
0000-0003-2750-8405
About
Panicos Shangaris is a Clinical Lecturer, subspecialising in Maternal & Fetal Medicine at KCL. He studied for a PhD at UCL funded by a Wellcome Trust SPARKS Research Training Fellowship and UCLH Charities on the subject: "Can we treat genetic blood disorders by transplantation of stem cells /gene therapy to the fetus?" under the supervision of Professor Anna David and Professor Paolo De Coppi. He has always been interested in research, fetal medicine, and therapy. For this reason, he took a year out of clinical training to study for an MSc in Prenatal Genetics and Fetal Medicine. UCLH Charities awarded him, with an entry-level fellowship for research in 2011 to start a PhD. In 2012, he was awarded the prestigious Wellcome Trust Sparks Research Training Fellowship to continue and complete his PhD. He has been involved in teaching science and medical students during tutorials, lectures and in the clinic. In addition, he had the opportunity to supervise science students during their research projects, with all students receiving merit or distinction in their projects. He is an Associate Fellow of the Higher Education Academy (AFHEA), in recognition of his contribution to teaching. He enjoys attending, networking and presenting at international conferences and during his Ph.D., he received nine national and international awards for conference presentations. He is planning to establish a stem cell research group focusing on in utero stem cell transplantation using immunotherapy, which is the research area of his mentor, Professor Giovanna Lombardi. This is an exciting, developing area, which combines stem cell research, immunology, and prenatal reprogramming. He is keen to form new collaborations with both scientists and clinicians.
Employment
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Kings College London Clinical Lecturer in Maternal & Fetal Medicine2019 - Present
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North Middlesex University Hospital Specialty Registrar2018 - 2019
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Royal Free London NHS Foundation Trust Specialty Registrar2015 - 2018
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University College London Wellcome Trust Sparks Research Training Fellow2013 - 2015
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Royal Free Hospital Specialty Registrar 32010 - 2011
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University College London Hospitals NHS Foundation Trust Specialty Registrar 22008 - 2009
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Chase Farm Hospital Specialty Registrar 12007 - 2008
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Burnley General Hospital Foundation Year 22006 - 2007
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East Lancashire Hospitals NHS Trust Foundation Year 12005 - 2006
Education
Education history is unavailable.
Projects & Funding
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Can we treat congenital blood disorders by transplantation of stem cells to the fetus Wellcome Trust2013 - 2015
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Can we treat congenital Blood disorders by transplantation of stem cells to the fetus? Sparks2013 - 2015
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An in utero stem cell transplantation gene therapy approach for prenatal therapy of thalassemia UCLH Charities2011 - 2013
Publications (77)
- Non‐Invasive Prenatal Diagnosis of Haemoglobinopathies: From Concept to Clinical Reality Save
- Chronic histiocytic intervillositis: Insights into immunopathogenesis and prospective treatments Save
- "You think everything's fine and then it starts not being fine" Save
- CAR-mediated release of IL-10 increases the function of regulatory T cells Save
- Maternal–foetal immune rejection: parallels between placental CHI and allograft rejection† Save
- Derivation, expansion and cryopreservation of primary fetal organoids from second and third trimester human amniotic fluid cells Save
- Chronic Histiocytic Intervillositis: Insights into Immunopathogenesis and Prospective Treatments Save
- Nanoneedle-Based Electroporation for Efficient Manufacturing of Human Primary Chimeric Antigen Receptor Regulatory T-Cells Save
- Assessment of the thymus in fetuses prior to spontaneous preterm birth using functional MRI Save
- Reduced GATA1 levels are associated with ineffective erythropoiesis in sickle cell anemia Save
- Gene editing efficiencies and hematopoietic stem cell fitness in sickle cell disease Save
- The Immunomodulatory Role of Regulatory T Cells in Preterm Birth and Associated Pregnancy Outcomes Save
- The Immunomodulatory Role of Regulatory T Cells in Preterm Birth and Associated Pregnancy Outcomes Save
- Oscillating autonomy Save
- Clinical value of placental examination for paediatricians Save
- Revolutionising healing Save
- The Role of Regulatory T Cells and Their Therapeutic Potential in Hypertensive Disease of Pregnancy Save
- Perinatal and neurodevelopmental outcomes of fetal isolated ventriculomegaly Save
- The Role of Regulatory T Cells and Their Therapeutic Potential in Hypertensive Disease of Pregnancy; A Literature Review Save
- Feticide Before Termination of Pregnancy in Singleton Pregnancy – Trends in England and Wales 2012–2020, a Cross-sectional Study Save