Benazir SIDDEEK
Centre Hospitalier Universitaire Vaudois, INSERM U1065, Lyon 1 Université, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
Research areas: Medicine · Pediatrics, Perinatology and Child Health · Birth, Development, and Health · Sperm and Testicular Function · Effects and risks of endocrine disrupting chemicals
0000-0003-2764-6656
About
My strength as a scientist lies in my longstanding research on the developmental programming of adult chronic diseases, with a particular focus on cardiovascular, kidney, placental, and testicular disorders. I have extensively investigated how early-life exposure to environmental challenges, especially nutritional excess, and endocrine-disrupting chemicals, can predispose individuals to long-term health consequences.
Through collaborative projects with major healthcare institutions (University Hospital Policlinico of Modena, Italy; CHU Lyon, CHU Nice, France; and CHUV Lausanne), research organizations (INSERM, France), and academic institutions (Universities of Lyon, Nice, Dijon in France, and UNIL in Lausanne), my work has contributed significantly to the field of Developmental Origins of Health and Disease (DOHaD).
Notably, my research has:
- Demonstrated the existence of critical developmental windows during which exposure to overnutrition or toxicants causes lasting organ dysfunction.
- Identified epigenetic mechanisms, particularly involving microRNAs, DNA methylation, and histone modifications that underlie these long-term effects.
Since joining the CHUV in Lausanne in 2014, I have played a key role in establishing the DOHaD laboratory. Driven by a commitment to advancing and sharing knowledge in this field, I have developed an independent research program focused on how early-life exposures, such as maternal obesity and environmental toxicants, program chronic disease risk. A major advancement from this work has been the identification of microRNAs and their biogenesis pathways as critical regulators and potential biomarkers of diseases.
Employment
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Centre Hospitalier Universitaire Vaudois Researcher2014 - Present
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INSERM U1065 Researcher2009 - 2014
- 2007 - 2009
Education
- 2003 - 2007
- 2002 - 2003
Projects & Funding
Projects & funding information is unavailable.
Publications (30)
- Maternal exposure to high-fat diet induces long-term mitochondrial alterations in the offspring heart Save
- Combined developmental exposure to estrogenic endocrine disruptor and nutritional imbalance induces long term adult prostate inflammation through inflammasome activation. Save
- Epigenetics provides a bridge between early nutrition and long‐term health and a target for disease prevention Save
- Transient Post-Natal Exposure to Xenoestrogens Induces Long-Term Alterations in Cardiac Calcium Signaling Save
- Intrauterine growth restriction: Clinical consequences on health and disease at adulthood Save
- Renal Programming by Transient Postnatal Overfeeding: The Role of Senescence Pathways Save
- Maternal Exposure to High-Fat Diet Induces Long-Term Derepressive Chromatin Marks in the Heart Save
- Calorie Restriction in Adulthood Reduces Hepatic Disorders Induced by Transient Postnatal Overfeeding in Mice Save
- Long-term impact of maternal high-fat diet on offspring cardiac health: role of micro-RNA biogenesis Save
- At the heart of programming: the role of micro-RNAs Save
- Effect of early postnatal nutrition on chronic kidney disease and arterial hypertension in adulthood: a narrative review Save
- Offspring of mothers with hyperglycaemia in pregnancy: The short term and long-term impact. What is new? Save
- Sperm epigenome as a marker of environmental exposure and lifestyle, at the origin of diseases inheritance Save
- Transient postnatal over nutrition induces long-term alterations in cardiac NLRP3-inflammasome pathway Save
- Improving cardiometabolic and mental health in women with gestational diabetes mellitus and their offspring: study protocol forMySweetHeart Trial, a randomised controlled trial Save
- Perinatal Origins of Adult Disease Save
- Transient postnatal overfeeding causes liver stress-induced premature senescence in adult mice Save
- Endothelial dysfunction in individuals born after fetal growth restriction: cardiovascular and renal consequences and preventive approaches Save
- Developmental epigenetic programming of adult germ cell death disease: Polycomb protein EZH2–miR-101 pathway Save
- Origine développementale et environnementale de l’infertilité masculine Save