AP
Alexandra T. P. Carvalho
Almac (United Kingdom), Center for Neuroscience and Cell Biology, Universidade do Porto, Almac Sciences Ltd/QUB
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Protein Structure and Dynamics · Enzyme Catalysis and Immobilization · Chemical Reaction Mechanisms
0000-0003-2827-5527
Employment
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Almac (United Kingdom) Technical Leader2021 - Present
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Center for Neuroscience and Cell Biology Assistant Investigator2017 - Present
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Almac Sciences Ltd/QUB Computational Chemist2015 - 2016
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Uppsala Universitet Researcher2013 - 2015
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Universitat de Girona BP fellow2012 - 2013
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Universidade do Porto post-doc2008 - 2012
Education
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Universidade do Porto PhD Computational Chemistry2004 - 2008
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Universidade do Porto Biochemistry1999 - 2003
Projects & Funding
Projects & funding information is unavailable.
Publications (99)
- Reactivity of Pseudozyma antarctica lipase B towards the synthesis of end-capped polycaprolactone for drug delivery Save
- Tripeptides Featuring Dehydrophenylalanine and Homophenylalanine: Homo- Versus Hetero-Chirality and Sequence Effects on Self-Assembly and Gelation Save
- BioStructNet: Structure-Based Network with Transfer Learning for Predicting Biocatalyst Functions Save
- Deciphering allosterism of an Escherichia coli hexuronate metabolism regulator: UxuR Save
- Papain-Mediated Conjugation of Peptide Nucleic Acids to Delivery Peptides: A Density Functional Theory/Molecular Mechanics Metadynamics Study in Aqueous and Organic Solvent Save
- Near‐Infrared Light Activated Formulation for the Spatially Controlled Release of CRISPR‐Cas9 Ribonucleoprotein for Brain Gene Editing Save
- Enzyme Screening and Engineering for N- and O-Demethylation: Key Steps in the Synthesis of Buprenorphine Save
- Application of rational enzyme engineering in a new route to etonogestrel and levonorgestrel: carbonyl reductase bioreduction of ethyl secodione Save
- Expanding the toolbox of Baeyer–Villiger and flavin monooxygenase biocatalysts for the enantiodivergent green synthesis of sulfoxides Save
- Discovery and Rational Mutagenesis of Methionine Sulfoxide Reductase Biocatalysts To Expand the Substrate Scope of the Kinetic Resolution of Chiral Sulfoxides Save
- Insights into the Degradation of Polymer–Drug Conjugates by an Overexpressed Enzyme in Cancer Cells Save
- Development of Enzymatic Variants for the Synthesis of Bioresorbable Polyesters Save
- Cell delivery peptides for small interfering RNAs targeting SARS-CoV-2 new variants through a bioinformatics and deep learning design Save
- An injectable, naproxen-conjugated, supramolecular hydrogel with ultra-low critical gelation concentrationprepared from a known folate receptor ligand Save
- Human Carboxylesterase 2 in Cocaine Metabolism Save
- Introduction of a Glycine Linker Connecting the Heavy and Light Chains in Synthetic Cardosin B-Derived Rennet Changes the Specificity of Subpocket S3′ Save
- Transcription factor allosteric regulation through substrate coordination to zinc Save
- A selective p53 activator and anticancer agent to improve colorectal cancer therapy Save
- Peptide Nucleic Acids modifications with enzymes Save
- Poly(e-caprolactone) enzymatic synthesis Save