SC
Sangkyun Cho
Johns Hopkins University, University of Pennsylvania, Stanford University
Research areas: Agricultural and Biological Sciences · Plant Science · Genetics and Plant Breeding · Soybean genetics and cultivation · Wheat and Barley Genetics and Pathology
0000-0003-2961-2847
Employment
-
Johns Hopkins University Assistant Professor2025 - Present
-
Stanford University Postdoctoral Fellow / Instructor2019 - 2025
-
University of Pennsylvania Graduate Student
Education
- 2013 - 2018
- ? - 2013
Projects & Funding
-
Elucidating the Role of Microenvironment Mechanics in Regulating Cardiac Myofibroblast Plasticity National Heart Lung and Blood Institute2023 - 2025
-
American Heart Association (AHA) Career Development Award American Heart Association2023 - Present
-
Human iPSCs for Elucidating Stress-mediated Paracrine Signaling in Dilated Cardiomyopathy National Heart Lung and Blood Institute2020 - 2022
-
Cardiovascular Imaging T32 Postdoctoral Training grant NIH2019 - 2020
Publications (26)
- Cardiac mechanotransduction from development to disease Save
- Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis Save
- Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate Save
- Challenges and opportunities for the next generation of cardiovascular tissue engineering. Save
- Heterozygous LMNA mutation-carrying iPSC lines from three cardiac laminopathy patients. Save
- Generation of three iPSC lines from dilated cardiomyopathy patients carrying a pathogenic LMNA variant. Save
- Scaling concepts in 'omics: Nuclear lamin-B scales with tumor growth and often predicts poor prognosis, unlike fibrosis. Save
- Reconstructing the heart using iPSCs: Engineering strategies and applications. Save
- An extracellular matrix paradox in myocardial scar formation. Save
- Single-cell RNA sequencing in cardiovascular development, disease and medicine. Save
- Tension in fibrils suppresses their enzymatic degradation - A molecular mechanism for 'use it or lose it'. Save
- Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest. Save
- Manipulating the mechanics of extracellular matrix to study effects on the nucleus and its structure Save
- Nuclear mechanosensing. Save
- Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. Save
- Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells. Save
- Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics. Save
- SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors. Save
- Mechanosensing of matrix by stem cells: From matrix heterogeneity, contractility, and the nucleus in pore-migration to cardiogenesis and muscle stem cells in vivo. Save
- Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation. Save